{"id":6241,"date":"2025-10-01T13:56:00","date_gmt":"2025-10-01T13:56:00","guid":{"rendered":"https:\/\/medicalaffairs.travere.com\/?post_type=publication&#038;p=6241"},"modified":"2025-10-15T11:55:55","modified_gmt":"2025-10-15T11:55:55","slug":"risk-factors-iga-nephropathy-cure-ckd-registry","status":"publish","type":"publication","link":"https:\/\/clleancode.top\/travere-redesign\/publications\/risk-factors-iga-nephropathy-cure-ckd-registry\/","title":{"rendered":"Population-Level Risk Factors for Kidney Outcomes in IgA Nephropathy: The CURE-CKD Registry"},"content":{"rendered":"\n\n\n\n<section class=\"o-hero-section o-hero--banner o-hero--blue o-hero--cropped\">\n    <img decoding=\"async\" width=\"1920\" height=\"767\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/10\/MCE1307-Travere-MA-Website-PDP-Pair-of-kidneys-V00-01-20240530.webp\" class=\"a-img a-img--right h-full\" alt=\"Hero Section Background Image\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/10\/MCE1307-Travere-MA-Website-PDP-Pair-of-kidneys-V00-01-20240530.webp 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/10\/MCE1307-Travere-MA-Website-PDP-Pair-of-kidneys-V00-01-20240530-300x120.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/10\/MCE1307-Travere-MA-Website-PDP-Pair-of-kidneys-V00-01-20240530-1024x409.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/10\/MCE1307-Travere-MA-Website-PDP-Pair-of-kidneys-V00-01-20240530-768x307.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/10\/MCE1307-Travere-MA-Website-PDP-Pair-of-kidneys-V00-01-20240530-1536x614.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/10\/MCE1307-Travere-MA-Website-PDP-Pair-of-kidneys-V00-01-20240530-290x116.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>    <div class=\"container\">\n        <div class=\"m-hero-inner m-hero-inner--post\">\n            <div class=\"m-breadcrumb\">\n                <nav class=\"breadcrumbs\" aria-label=\"breadcrumb\"><span><span><a href=\"https:\/\/clleancode.top\/travere-redesign\/\">Home<\/a><\/span><\/span><\/nav>            <\/div>\n            <h1 class=\"a-heading a-heading--h1 h-white\">Population-Level Risk Factors for Kidney Outcomes in IgA Nephropathy: The CURE-CKD Registry<\/h1>                    <\/div>\n    <\/div>\n<\/section>\n\n\r\n\t<section style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;margin-top:calc(-150px * var(--scale));\" class=\"section-container wp-elements-86239ce926d7a35d108f1aef5c3bde64 wp-block-grizzly-section-container has-text-color has-white-color\">\r\n\t\t\t\t<div class=\"container\">\r\n\t\t\t\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\">\n<div class=\"info-block info-block-publication search__container-publication search__container\">\n\t<div class=\"info-block-top\">\n\t\t<div>\n\t\t\t\t\t\t\t<div class=\"info-block-type\"><i class=\"icon2-journal\"><\/i> Journal article<\/div>\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"info-block-type\">\n\t\t\t\t\t<i class=\"icon2-calendar\"><\/i> Published on February 13, 2025\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t<p>Topics: <\/p>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">Nephrology<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">IgAN<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\t<div class=\"info-block-bottom\">\n\t\t\t\t\t<div class=\"info-block-box\">\n\t\t\t\tContributors:<br \/><span>Tuttle K, Kornowske L, Jones C et al.<\/span>\n\t\t\t<\/div>\n\t\t\n\t\t<div class=\"info-block-box\">\n\t\t\t\t\t\t\tName of Journal:<br \/><span>Kidney Medicine<\/span><br \/><br \/><br \/>\n\t\t\t\n\t\t\t\t\t\t\t<a href=\"#\" 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class=\"breadcrumb_last\" aria-current=\"page\">Population-Level Risk Factors for Kidney Outcomes in IgA Nephropathy: The CURE-CKD Registry<\/span><\/span><\/div>\n\n\n<h2 class=\"wp-block-heading has-text-align-center has-heading-4-font-size has-teal-color has-text-color has-link-color wp-elements-ede920955d44453a92ea834011b25155\" id=\"h-summary\" style=\"margin-top:calc(60px * var(--scale));margin-bottom:calc(30px * var(--scale))\"><span class=\"fw-600\">Summary<\/span><br><\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-text-align-left has-heading-5-font-size\" id=\"h-population-level-data-from-the-center-for-kidney-disease-research-education-and-hope-cure-ckd-registry-were-used-to-identify-iga-nephropathy-risk-factors-of-major-adverse-kidney-events-make-1\"><span class=\"fw-600\">Population-level data from the Center for Kidney Disease Research,Education, and Hope (CURE-CKD) Registry were used to identify IgA nephropathy risk factors of major adverse kidney events (MAKE)<sup>1<\/sup><\/span><\/h3>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-heading-5-font-size\" id=\"h-background\"><br><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\"><span class=\"fw-600\">Background<\/span><\/mark><\/h4>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>IgA nephropathy is a glomerular disease found in populations worldwide.<sup>2<\/sup> Low <mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-teal-color\"><span class=\"text-decoration-underline\"><a href=\"https:\/\/medicalaffairs.travere.com\/publications\/long-term-outcomes-in-iga-nephropathy\/\">estimated glomerular filtration rate (eGFR), proteinuria<\/a><\/span><\/mark>, and histologic findings are established prognostic markers, while other IgA nephropathy risk factors such as population-level variables like health insurance status and healthcare utilization have not been explored.<sup>1,3<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-aim\"><br><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\"><span class=\"fw-600\">Aim<\/span><\/mark><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The aim of this study is to assess the impact of demographic, clinical, and population-level characteristics on the risk of major adverse kidney events (MAKE) in adults with IgA nephropathy using the Center for Kidney Disease Research, Education, and Hope (CURE-CKD) registry.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-approach\"><br><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\"><span class=\"fw-600\">Approach<\/span><\/mark><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>A longitudinal, real-world cohort study was conducted between 2016 and 2022, using data from 2,571 adults with IgA nephropathy from Providence and University of California Los Angeles (UCLA) Health Systems\u2019 records within the CURE-CKD registry.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Predictors included:<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li>Age<\/li>\n\n\n\n<li>Gender<\/li>\n\n\n\n<li>Race<\/li>\n\n\n\n<li>eGFR<\/li>\n\n\n\n<li>Urine albumin-creatinine ratio (UACR)<\/li>\n\n\n\n<li>Urine protein-creatinine ratio (UPCR)<\/li>\n\n\n\n<li>Diabetes<\/li>\n\n\n\n<li>Hypertension<\/li>\n\n\n\n<li>Medications<\/li>\n\n\n\n<li>Health insurance type<\/li>\n\n\n\n<li>Hospitalization<\/li>\n\n\n\n<li>Outpatient visit frequency<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Outcomes included time to first MAKE, defined as \u226540% eGFR decline, eGFR &lt;15 mL\/min\/1.73 m<sup>2<\/sup>, kidney failure, dialysis\/transplant, or death.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-findings\"><br><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\"><span class=\"fw-600\">Findings<\/span><\/mark><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">The majority of the full cohort with IgA nephropathy was from the&nbsp;Providence health system (74%, 1,905\/2,571)<sup>1<\/sup><\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li>Gender: 50% (1,277\/2,571) women<sup>1<\/sup>&nbsp;<\/li>\n\n\n\n<li>Mean age (\u00b1 SD): 58 \u00b1 18 years old at baseline<sup>1<\/sup><\/li>\n\n\n\n<li>Asian race: 13% (325\/2,571)<sup>1<\/sup>&nbsp;<\/li>\n\n\n\n<li>53% (1,354\/2,571) had commercial health insurance as the primary payer<\/li>\n\n\n\n<li>Comorbidities<sup>1<\/sup>&nbsp;<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:8px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul style=\"padding-left:calc(40px * var(--scale))\" class=\"wp-block-list\">\n<li>Diabetes was present in 28% (708\/2,571)<\/li>\n\n\n\n<li>Hypertension was present in 75% (1,919\/2,571)<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li>Treatment modalities<sup>1<\/sup><\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:8px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul style=\"padding-left:calc(40px * var(--scale))\" class=\"wp-block-list\">\n<li>Angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARB) were used by 49% (1,250\/2,571)<\/li>\n\n\n\n<li>Corticosteroids and other immunomodulators were used by 39% (1,006\/2,571) and 3% (77\/2,571), respectively<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">Within 3 years (median follow-up 2.8 years), 22% (536\/2,571) experienced MAKE<sup>1<\/sup><\/span><\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>MAKE was comprised of<sup>1<\/sup>:<\/p>\n\n\n\n<div style=\"height:8px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li>61% (327\/536) \u226540% eGFR decline<\/li>\n\n\n\n<li>20% (108\/536) kidney failure with eGFR &lt;15 mL\/min\/1.73 m<sup>2<\/sup><\/li>\n\n\n\n<li>4% (23\/536) dialysis<\/li>\n\n\n\n<li>3% (17\/536) transplant<\/li>\n\n\n\n<li>11% (61\/536) all-cause death<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">Several predictors significantly increased the hazard of MAKE<sup>1<\/sup>:<\/span><\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li>Hospitalization (HR=2.59; 95% CI, 2.14-3.12)<\/li>\n\n\n\n<li>Other immunomodulators (HR=1.59; 95% CI, 1.09-2.30)<\/li>\n\n\n\n<li>Non-commercial health insurance (HR=1.46; 95% CI, 1.19-1.80)<\/li>\n\n\n\n<li>Low eGFR (HR=1.28; 95% CI, 1.24-1.33)<\/li>\n\n\n\n<li>Diabetes (HR=1.30; 95% CI, 1.07-1.57)<\/li>\n\n\n\n<li>ACE inhibitor or ARB use (HR=1.26; 95% CI, 1.04-1.53)<\/li>\n\n\n\n<li>Outpatient visits (HR=1.01; 95% CI, 1.00-1.03)<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\">\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-key-takeaway\"><br><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\"><span class=\"fw-600\">Key takeaway<\/span><\/mark><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>In this large, diverse US cohort, using real-world data, both clinical and non-clinical IgA nephropathy risk factors, including insurance type, hospitalization, and more frequent outpatient encounters, predicted MAKE.<sup>1<\/sup> Incorporating these population-level factors into risk models may help to stratify patients with IgA nephropathy and enable a population health approach within health systems for monitoring and therapeutic interventions to reduce risks.<sup>1<\/sup><br><br><br><\/p>\n\n\n\n<div class=\"newsletter\">\n\t<div class=\"newsletter-icon\">\n\t\t<span class=\"icon2-newsletter\"><\/span>\n\t<\/div>\n\t<div class=\"newsletter-text\">\n\t\t<p><strong>Sign up<\/strong> to receive scientific updates<br \/>\nfor healthcare professionals<br \/>\nfrom Travere Therapeutics.<\/p>\n\t<\/div>\n\t<div class=\"newsletter-form\">\n\t\t<script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\nvar 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\t\t\t\t\t2024\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/kidney-failure-iga-nephropathy-usrds-cohort-study\/\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: Kidney Failure Attributed to Immunoglobulin A Nephropathy: A USRDS Retrospective Cohort Study of Epidemiology, Treatment Modalities, and Economic Burden\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t<article class=\"m-card  \" aria-label=\"Publication card: Kidney Failure Events, Cardiovascular Disease Events, and All-Cause Mortality in Immunoglobulin A Nephropathy Patients in a Real-World Database\">\n\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/iga-nephropathy-mortality-kidney-failure-cardiovascular-disease-real-world\/\"  aria-label=\"View publication: Kidney Failure Events, Cardiovascular Disease Events, and All-Cause Mortality in Immunoglobulin A Nephropathy Patients in a Real-World Database\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1920\" height=\"1080\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header.png\" class=\"a-img\" alt=\"Kidney Failure Events, Cardiovascular Disease Events, and All-Cause Mortality in Immunoglobulin A Nephropathy Patients in a Real-World Database\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header.png 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-300x169.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-1024x576.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-768x432.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-1536x864.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-290x163.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t<\/a>\n\t\t\t<div class=\"m-card__info\">\n\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t<span class=\"a-tag h-blue\">\n\t\t\t\t\t\t<i class=\"icon4 icon4-publication\"><\/i> Publication\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"a-tag h-blue\">Nephrology<\/span><span class=\"a-tag h-blue\">IgAN<\/span>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t<div class=\"m-card__text\">\n\t\t\t\t<p class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\tKidney Failure Events, Cardiovascular Disease Events, and All-Cause Mortality in Immunoglobulin A Nephropathy Patients in a Real-World Database\t\t\t\t<\/p>\n\t\t\t\t<p class=\"a-text a-text--m h-ultra-dark-blue\">\n\t\t\t\t\t<em>Kidney360<\/em> \n\t\t\t\t\t &#8211; \t\t\t\t\t2024\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/iga-nephropathy-mortality-kidney-failure-cardiovascular-disease-real-world\/\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: Kidney Failure Events, Cardiovascular Disease Events, and All-Cause Mortality in Immunoglobulin A Nephropathy Patients in a Real-World Database\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t<article class=\"m-card  \" aria-label=\"Publication card: Long-Term Outcomes in IgA Nephropathy\">\n\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/long-term-outcomes-in-iga-nephropathy\/\"  aria-label=\"View publication: Long-Term Outcomes in IgA Nephropathy\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1920\" height=\"767\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1.png\" class=\"a-img\" alt=\"Long-Term Outcomes in IgA Nephropathy\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1.png 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1-300x120.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1-1024x409.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1-768x307.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1-1536x614.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1-290x116.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t<\/a>\n\t\t\t<div class=\"m-card__info\">\n\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t<span class=\"a-tag h-blue\">\n\t\t\t\t\t\t<i class=\"icon4 icon4-publication\"><\/i> Publication\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"a-tag h-blue\">Nephrology<\/span><span class=\"a-tag h-blue\">IgAN<\/span>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t<div class=\"m-card__text\">\n\t\t\t\t<p class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\tLong-Term Outcomes in IgA Nephropathy\t\t\t\t<\/p>\n\t\t\t\t<p class=\"a-text a-text--m h-ultra-dark-blue\">\n\t\t\t\t\t<em>Clinical Journal of the American Society of Nephrology<\/em> \n\t\t\t\t\t &#8211; \t\t\t\t\t2023\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/long-term-outcomes-in-iga-nephropathy\/\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: Long-Term Outcomes in IgA Nephropathy\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t\t<\/div>\n\t\t<div class=\"publication-related-btn\">\n\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/\" class=\"a-btn a-btn--primary\" aria-label=\"See more\">See more<\/a>\n\t\t<\/div>\n\t<\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading has-ocean-blue-color has-text-color has-link-color wp-elements-f1b50e7f518d9777cc0aa8a5c07c631d\" id=\"h-footnotes\" style=\"margin-bottom:calc(30px * var(--scale))\"><strong>Footnotes<\/strong><\/h5>\n\n\n\n<p class=\"has-small-font-size\" style=\"margin-bottom:0px\">This study was funded through an investigator-initiated grant from Travere Therapeutics Inc. Please see the publication for the full list of disclosures.<\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-small-font-size\" style=\"margin-bottom:0px\">ACE, angiotensin-converting enzyme; ARB, angiotensin receptor blocker; CI, confidence interval; CURE-CKD, Center for Kidney Disease Research,<\/p>\n\n\n\n<p class=\"has-small-font-size\" style=\"margin-bottom:0px\">Education, and Hope; eGFR, estimated glomerular filtration rate; HR, hazard ratio; MAKE, major adverse kidney event; UACR, albumin-creatinine ratio; UPCR, urine protein-creatinine ratio; UCLA, University of California Los Angeles.<\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ol class=\"wp-block-list\">\n<li class=\"has-small-font-size\">Tuttle KR, Kornowske LM, Jones CR et al. <em>Kidney Med<\/em>. 2025;7:100981.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Rodrigues JC, Haas M, Reich HN. <em>Clin J Am Soc Nephrol<\/em>. 2017;12(4):677-686.&nbsp;<\/li>\n\n\n\n<li class=\"has-small-font-size\">Howie AJ, Lalayiannis AD. <em>Kidney360<\/em>. 2023;4(8):1103-1111.<\/li>\n<\/ol>\n<\/div>\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-right\" style=\"margin-top:calc(30px * var(--scale));margin-bottom:calc(300px * var(--scale))\">MA-DS-25-0090 | September 2025<\/p>\n<\/div>\n\n\t\t<\/div>\r\n\t<\/section>\r\n\t","protected":false},"featured_media":7224,"template":"","meta":{"inline_featured_image":false,"header_bg_color":"transparent","header_fixed":true,"post_description":"","post_download_link":"","journal_link":"https:\/\/www.kidneymedicinejournal.org\/article\/S2590-0595(25)00017-2\/fulltext","pdf_file_link":""},"product":[142],"therapeutic_area":[97],"disease_area":[174],"study_registry":[246],"study_type":[183],"resource_type":[177,180],"class_list":["post-6241","publication","type-publication","status-publish","has-post-thumbnail","hentry","product-non-product-disease-state","therapeutic_area-neph","disease_area-igan","study_registry-cure-ckd","study_type-rwe","resource_type-publication","resource_type-summary"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.9 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Population-Level Risk Factors for Kidney 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