{"id":6237,"date":"2025-09-26T00:32:21","date_gmt":"2025-09-26T00:32:21","guid":{"rendered":"https:\/\/medicalaffairs.travere.com\/?post_type=publication&#038;p=6237"},"modified":"2025-10-15T11:57:13","modified_gmt":"2025-10-15T11:57:13","slug":"long-term-outcomes-nephrotic-syndrome-biopsy-proteinuria","status":"publish","type":"publication","link":"https:\/\/clleancode.top\/travere-redesign\/publications\/long-term-outcomes-nephrotic-syndrome-biopsy-proteinuria\/","title":{"rendered":"Long-Term Outcomes in Nephrotic Syndrome by Kidney Biopsy Diagnosis and Proteinuria"},"content":{"rendered":"\n\n\n\n<section class=\"o-hero-section o-hero--banner o-hero--blue o-hero--cropped\">\n    <img decoding=\"async\" width=\"1920\" height=\"767\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/10\/MCE1307-Travere-MA-Website-PDP-Pair-of-kidneys-V00-01-20240530.webp\" class=\"a-img a-img--right h-full\" alt=\"Hero Section Background Image\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/10\/MCE1307-Travere-MA-Website-PDP-Pair-of-kidneys-V00-01-20240530.webp 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/10\/MCE1307-Travere-MA-Website-PDP-Pair-of-kidneys-V00-01-20240530-300x120.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/10\/MCE1307-Travere-MA-Website-PDP-Pair-of-kidneys-V00-01-20240530-1024x409.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/10\/MCE1307-Travere-MA-Website-PDP-Pair-of-kidneys-V00-01-20240530-768x307.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/10\/MCE1307-Travere-MA-Website-PDP-Pair-of-kidneys-V00-01-20240530-1536x614.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/10\/MCE1307-Travere-MA-Website-PDP-Pair-of-kidneys-V00-01-20240530-290x116.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>    <div class=\"container\">\n        <div class=\"m-hero-inner m-hero-inner--post\">\n            <div class=\"m-breadcrumb\">\n                <nav class=\"breadcrumbs\" aria-label=\"breadcrumb\"><span><span><a href=\"https:\/\/clleancode.top\/travere-redesign\/\">Home<\/a><\/span><\/span><\/nav>            <\/div>\n            <h1 class=\"a-heading a-heading--h1 h-white\">Long-Term Outcomes in Nephrotic Syndrome by Kidney Biopsy Diagnosis and Proteinuria<\/h1>                    <\/div>\n    <\/div>\n<\/section>\n\n\r\n\t<section style=\"margin-top:calc(-150px * var(--scale));\" class=\"section-container wp-elements-9e22dc5a3cc971cffd623186eca0f6b9 wp-block-grizzly-section-container has-text-color has-white-color\">\r\n\t\t\t\t<div class=\"container\">\r\n\t\t\t\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\">\n<div class=\"info-block info-block-publication search__container-publication search__container\">\n\t<div class=\"info-block-top\">\n\t\t<div>\n\t\t\t\t\t\t\t<div class=\"info-block-type\"><i class=\"icon2-journal\"><\/i> Journal article<\/div>\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"info-block-type\">\n\t\t\t\t\t<i class=\"icon2-calendar\"><\/i> Published on April 17, 2025\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t<p>Topics: <\/p>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">Nephrology<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">FSGS<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\t<div class=\"info-block-bottom\">\n\t\t\t\t\t<div class=\"info-block-box\">\n\t\t\t\tContributors:<br \/><span>Pitcher D, Braddon F, Hendry B et al.<\/span>\n\t\t\t<\/div>\n\t\t\n\t\t<div class=\"info-block-box\">\n\t\t\t\t\t\t\tName of Journal:<br \/><span>Journal of the American Society of Nephrology<\/span><br \/><br \/><br \/>\n\t\t\t\n\t\t\t\t\t\t\t<a href=\"#\" data-url=\"https:\/\/journals.lww.com\/jasn\/fulltext\/2025\/07000\/long_term_outcomes_in_nephrotic_syndrome_by_kidney.17.aspx\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"btn btn-outline leaving-modal-toggle btn-leaving\" aria-label=\"View Publication\">View Publication<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"info-block-box info-block-doi\">\n\t\t\t\tDOI:<br \/><span>10.1681\/ASN.0000000610<\/span>\n\t\t\t<\/div>\n\t\t\n\t\t<div class=\"info-block-share\">Share:\n\t\t\t<span>\n\t\t\t\t\t<a href=\"https:\/\/twitter.com\/intent\/tweet?url=https%3A%2F%2Fclleancode.top%2Ftravere-redesign%2Fpublications%2Flong-term-outcomes-nephrotic-syndrome-biopsy-proteinuria%2F&#038;text=Long-Term+Outcomes+in+Nephrotic+Syndrome+by+Kidney+Biopsy+Diagnosis+and+Proteinuria\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"icon2-x\" aria-label=\"Share on Twitter\"><\/a> \n\t<a 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For more information, review the <a href=\"https:\/\/travere.com\/privacy\/\" target=\"_blank\">Travere privacy policies<\/a>.<\/span><\/label><\/span><\/span><\/span>\n  <\/div>\n  <div class=\"form-group text-right\">\n    <input class=\"wpcf7-form-control wpcf7-submit has-spinner btn\" id=\"request-submit\" type=\"submit\" value=\"Yes, continue\" \/>\n  <\/div>\n<\/div><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div> <\/div>\n\n\t\t<\/div>\r\n\t<\/section>\r\n\t\n\n\r\n\t<section class=\"section-container wp-block-grizzly-section-container\">\r\n\t\t\t\t<div class=\"container\">\r\n\t\t\t\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading has-text-align-center has-heading-4-font-size has-teal-color has-text-color has-link-color wp-elements-ede920955d44453a92ea834011b25155\" id=\"h-summary\" style=\"margin-top:calc(60px * var(--scale));margin-bottom:calc(30px * var(--scale))\"><span class=\"fw-600\">Summary<\/span><br><\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-text-align-left has-heading-5-font-size\" id=\"h-analysis-of-the-uk-national-registry-of-rare-kidney-diseases-radar-highlights-the-significant-burden-of-idiopathic-nephrotic-syndrome-1\"><span class=\"fw-600\">Analysis of the UK National Registry of Rare Kidney Diseases (RaDaR) highlights the significant burden of idiopathic nephrotic syndrome<sup>1<\/sup><\/span><\/h3>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-heading-5-font-size\" id=\"h-background\"><br><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\"><span class=\"fw-600\">Background<\/span><\/mark><\/h4>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Idiopathic nephrotic syndrome encompasses distinct subtypes \u2014 monogenic nephrotic syndrome, focal segmental glomerulosclerosis (FSGS), and minimal change disease (MCD) \u2014 that disrupt the glomerular filtration barrier.<sup>1,2<\/sup><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The impact of proteinuria control on long-term kidney outcomes in idiopathic nephrotic syndrome has not been fully characterized across large, well-defined cohorts, but in some subsets, achieving complete or partial proteinuria remission has been associated with better outcomes.<sup>1,3<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-aim\"><br><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\"><span class=\"fw-600\">Aim<\/span><\/mark><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The aim of this study was to evaluate long-term kidney survival and estimated glomerular filtration rate (eGFR) decline in patients with idiopathic nephrotic syndrome by histologic\/genetic subtype and to quantify the relationship between early proteinuria reduction and the risk of kidney failure or death.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-approach\"><br><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\"><span class=\"fw-600\">Approach<\/span><\/mark><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>This retrospective study used data from the UK National Registry of Rare Kidney Diseases (RaDaR) idiopathic nephrotic syndrome cohort (including adults and children with genetic nephrotic syndrome, biopsy-confirmed primary FSGS, or MCD) to assess long-term outcomes.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-findings\"><br><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\"><span class=\"fw-600\">Findings<\/span><\/mark><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">The study population included subgroups of patients in the idiopathic nephrotic syndrome cohort<sup>1<\/sup><\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The total cohort included 4,066 patients (2,467 adults; 1,599 children) with biopsy-confirmed FSGS or MCD, or genetically confirmed nephrotic syndrome.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">Kidney survival rates varied across the nephrotic syndrome subgroups<sup>1<\/sup><\/span><\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Kidney survival rate at 10 years<sup>1<\/sup>:<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li>Genetic nephrotic syndrome: 29% (95% confidence interval [CI]: 20-38)<\/li>\n\n\n\n<li>FSGS: 58% (95% CI: 55-61)<\/li>\n\n\n\n<li>MCD: 87% (95% CI: 85-89)<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">Survival from kidney failure correlated with greater proteinuria remission (stratified by lowest proteinuria value 6-12 months after baseline)<sup>1<\/sup><\/span><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Survival rate in patients with FSGS at 10 years<sup>1<\/sup>:<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li>Complete remission (&lt;0.3 g\/g): 88% (95% CI: 70-96)<\/li>\n\n\n\n<li>Partial remission (0.3-3.5 g\/g): 65% (95% CI: 50-76)<\/li>\n\n\n\n<li>No remission (&gt;3.5 g\/g): 37% (95% CI: 26-48)<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Survival rate in patients with MCD at 10 years<sup>1<\/sup>:<\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li>Complete remission (&lt;0.3 g\/g): 89% (95% CI: 79-94)<\/li>\n\n\n\n<li>Partial remission (0.3-3.5 g\/g): 75% (95% CI: 51-89)<\/li>\n\n\n\n<li>No remission (&gt;3.5 g\/g): 64% (95% CI: 41-81)<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">In both FSGS and MCD subtypes, eGFR slope over 10 years strongly correlated with absolute levels of proteinuria<sup>1<\/sup><\/span><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Patients with FSGS experience a more rapid decline in kidney function and higher rates of kidney failure despite receiving treatments targeting proteinuria reduction.<sup>1<\/sup> Patients with MCD generally experienced better outcomes than those with FSGS.<sup>1<\/sup><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\">\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-key-takeaway\"><br><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\"><span class=\"fw-600\">Key takeaway<\/span><\/mark><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>In idiopathic nephrotic syndrome, long-term kidney survival varies markedly by diagnosis.<sup>1<\/sup> At the same levels of proteinuria, patients with biopsies showing FSGS are at a higher risk for poor outcomes than those with biopsies confirming MCD.<sup>1<\/sup> Achieving early, sustained proteinuria reduction significantly improved outcomes, underscoring proteinuria as a critical prognostic and therapeutic target in clinical care and trial design in nephrotic syndrome.<sup>1<\/sup><br><br><br><br><\/p>\n\n\n\n<div class=\"newsletter\">\n\t<div class=\"newsletter-icon\">\n\t\t<span class=\"icon2-newsletter\"><\/span>\n\t<\/div>\n\t<div class=\"newsletter-text\">\n\t\t<p><strong>Sign up<\/strong> to receive scientific updates<br \/>\nfor healthcare professionals<br \/>\nfrom Travere Therapeutics.<\/p>\n\t<\/div>\n\t<div 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\t\t\t\t\t2025\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/fsgs-patient-carepartner-burden\/\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: The Humanistic Burden of Focal Segmental Glomerulosclerosis on Patients and Care\u2011Partners in the United States\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"swiper-progressbar\"><\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"publication-related-grid search-items__grid search__container\" id=\"search__container\" style=\"display: flex;\">\n\t\t\t\t<article class=\"m-card  \" aria-label=\"Publication card: Kidney Failure Attributed to Focal Segmental Glomerulosclerosis: A USRDS Retrospective Cohort Study of Epidemiology, Treatment Modalities, and Economic Burden\">\n\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/?post_type=publication&#038;p=4961\"  aria-label=\"View publication: Kidney Failure Attributed to Focal Segmental Glomerulosclerosis: A USRDS Retrospective Cohort Study of Epidemiology, Treatment Modalities, and Economic Burden\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1920\" height=\"767\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/Group-of-people-header.png\" class=\"a-img\" alt=\"Kidney Failure Attributed to Focal Segmental Glomerulosclerosis: A USRDS Retrospective Cohort Study of Epidemiology, Treatment Modalities, and Economic Burden\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/Group-of-people-header.png 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/Group-of-people-header-300x120.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/Group-of-people-header-1024x409.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/Group-of-people-header-768x307.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/Group-of-people-header-1536x614.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/Group-of-people-header-290x116.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t<\/a>\n\t\t\t<div class=\"m-card__info\">\n\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t<span class=\"a-tag h-blue\">\n\t\t\t\t\t\t<i class=\"icon4 icon4-publication\"><\/i> Publication\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"a-tag h-blue\">Nephrology<\/span><span class=\"a-tag h-blue\">FSGS<\/span>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t<div class=\"m-card__text\">\n\t\t\t\t<p class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\tKidney Failure Attributed to Focal Segmental Glomerulosclerosis: A USRDS Retrospective Cohort Study of Epidemiology, Treatment Modalities, and Economic Burden\t\t\t\t<\/p>\n\t\t\t\t<p class=\"a-text a-text--m h-ultra-dark-blue\">\n\t\t\t\t\t<em>Kidney Medicine<\/em> \n\t\t\t\t\t &#8211; \t\t\t\t\t2023\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/?post_type=publication&#038;p=4961\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: Kidney Failure Attributed to Focal Segmental Glomerulosclerosis: A USRDS Retrospective Cohort Study of Epidemiology, Treatment Modalities, and Economic Burden\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t<article class=\"m-card  \" aria-label=\"Publication card: Cardiovascular,  Kidney Failure,  and All-Cause Mortality Events in Patients with Focal Segmental Glomerulosclerosis in a U.S.  Real-World Database\">\n\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/cardiovascular-kidney-failure-mortality-fsgs-real-world\/\"  aria-label=\"View publication: Cardiovascular,  Kidney Failure,  and All-Cause Mortality Events in Patients with Focal Segmental Glomerulosclerosis in a U.S.  Real-World Database\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1920\" height=\"1080\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header.png\" class=\"a-img\" alt=\"Cardiovascular,  Kidney Failure,  and All-Cause Mortality Events in Patients with Focal Segmental Glomerulosclerosis in a U.S.  Real-World Database\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header.png 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-300x169.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-1024x576.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-768x432.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-1536x864.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-290x163.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t<\/a>\n\t\t\t<div class=\"m-card__info\">\n\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t<span class=\"a-tag h-blue\">\n\t\t\t\t\t\t<i class=\"icon4 icon4-publication\"><\/i> Publication\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"a-tag h-blue\">Nephrology<\/span><span class=\"a-tag h-blue\">FSGS<\/span>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t<div class=\"m-card__text\">\n\t\t\t\t<p class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\tCardiovascular,  Kidney Failure,  and All-Cause Mortality Events in Patients with Focal Segmental Glomerulosclerosis in a U.S.  Real-World Database\t\t\t\t<\/p>\n\t\t\t\t<p class=\"a-text a-text--m h-ultra-dark-blue\">\n\t\t\t\t\t<em>Kidney360<\/em> \n\t\t\t\t\t &#8211; \t\t\t\t\t2024\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/cardiovascular-kidney-failure-mortality-fsgs-real-world\/\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: Cardiovascular,  Kidney Failure,  and All-Cause Mortality Events in Patients with Focal Segmental Glomerulosclerosis in a U.S.  Real-World Database\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t<article class=\"m-card  \" aria-label=\"Publication card: The Humanistic Burden of Focal Segmental Glomerulosclerosis on Patients and Care\u2011Partners in the United States\">\n\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/fsgs-patient-carepartner-burden\/\"  aria-label=\"View publication: The Humanistic Burden of Focal Segmental Glomerulosclerosis on Patients and Care\u2011Partners in the United States\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1920\" height=\"767\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/04\/MCE1307-Travere-MA-Website-PDP-Group-of-people-V00-01-20240530.webp\" class=\"a-img\" alt=\"The Humanistic Burden of Focal Segmental Glomerulosclerosis on Patients and Care\u2011Partners in the United States\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/04\/MCE1307-Travere-MA-Website-PDP-Group-of-people-V00-01-20240530.webp 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/04\/MCE1307-Travere-MA-Website-PDP-Group-of-people-V00-01-20240530-300x120.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/04\/MCE1307-Travere-MA-Website-PDP-Group-of-people-V00-01-20240530-1024x409.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/04\/MCE1307-Travere-MA-Website-PDP-Group-of-people-V00-01-20240530-768x307.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/04\/MCE1307-Travere-MA-Website-PDP-Group-of-people-V00-01-20240530-1536x614.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/04\/MCE1307-Travere-MA-Website-PDP-Group-of-people-V00-01-20240530-290x116.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t<\/a>\n\t\t\t<div class=\"m-card__info\">\n\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t<span class=\"a-tag h-blue\">\n\t\t\t\t\t\t<i class=\"icon4 icon4-publication\"><\/i> Publication\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"a-tag h-blue\">Nephrology<\/span><span class=\"a-tag h-blue\">FSGS<\/span>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t<div class=\"m-card__text\">\n\t\t\t\t<p class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\tThe Humanistic Burden of Focal Segmental Glomerulosclerosis on Patients and Care\u2011Partners in the United States\t\t\t\t<\/p>\n\t\t\t\t<p class=\"a-text a-text--m h-ultra-dark-blue\">\n\t\t\t\t\t<em>Quality of Life Research<\/em> \n\t\t\t\t\t &#8211; \t\t\t\t\t2025\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/fsgs-patient-carepartner-burden\/\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: The Humanistic Burden of Focal Segmental Glomerulosclerosis on Patients and Care\u2011Partners in the United States\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t\t<\/div>\n\t\t<div class=\"publication-related-btn\">\n\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/\" class=\"a-btn a-btn--primary\" aria-label=\"See more\">See more<\/a>\n\t\t<\/div>\n\t<\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading has-ocean-blue-color has-text-color has-link-color wp-elements-f1b50e7f518d9777cc0aa8a5c07c631d\" id=\"h-footnotes\" style=\"margin-bottom:calc(30px * var(--scale))\"><strong>Footnotes<\/strong><\/h5>\n\n\n\n<p class=\"has-small-font-size\" style=\"margin-bottom:calc(30px * var(--scale))\">This work was supported by Travere Therapeutics, Inc. Please see the publication for the full list of disclosures.<\/p>\n\n\n\n<p class=\"has-small-font-size\" style=\"margin-bottom:calc(30px * var(--scale))\">CI, confidence interval; eGFR, estimated glomerular filtration rate; FSGS, focal segmental glomerulosclerosis; MCD, minimal change disease; RaDaR, National Registry of Rare Kidney Diseases.<\/p>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ol class=\"wp-block-list\">\n<li class=\"has-small-font-size\">Pitcher D et al. <em>J Am Soc Nephrol<\/em>. 2025;36(7):1398-1413.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Colby E et al. <em>Clin Kidney J.<\/em> 2024;17(8):sfae096.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Troyanov S et al. <em>J Am Soc Nephrol.<\/em> 2005;16(4):1061-1068.<\/li>\n<\/ol>\n<\/div>\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-right\" style=\"margin-top:calc(30px * var(--scale));margin-bottom:calc(300px * var(--scale))\">MA-DS-25-0089 | September 2025<\/p>\n<\/div>\n\n\t\t<\/div>\r\n\t<\/section>\r\n\t","protected":false},"featured_media":7224,"template":"","meta":{"inline_featured_image":false,"header_bg_color":"transparent","header_fixed":true,"post_description":"","post_download_link":"","journal_link":"https:\/\/journals.lww.com\/jasn\/fulltext\/2025\/07000\/long_term_outcomes_in_nephrotic_syndrome_by_kidney.17.aspx","pdf_file_link":"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/07\/Pitcher-JASN-2025.pdf"},"product":[142],"therapeutic_area":[97],"disease_area":[186],"study_registry":[184],"study_type":[182,183],"resource_type":[177,180],"class_list":["post-6237","publication","type-publication","status-publish","has-post-thumbnail","hentry","product-non-product-disease-state","therapeutic_area-neph","disease_area-fsgs","study_registry-radar","study_type-observational","study_type-rwe","resource_type-publication","resource_type-summary"],"yoast_head":"<!-- This site is optimized with the 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