{"id":5334,"date":"2019-12-13T21:45:00","date_gmt":"2019-12-13T21:45:00","guid":{"rendered":"https:\/\/medicalaffairs.travere.com\/?post_type=publication&#038;p=5334"},"modified":"2025-10-01T00:00:05","modified_gmt":"2025-10-01T00:00:05","slug":"quality-of-life-cystinuria-tiopronin-therapy","status":"publish","type":"publication","link":"https:\/\/clleancode.top\/travere-redesign\/publications\/quality-of-life-cystinuria-tiopronin-therapy\/","title":{"rendered":"Assessment of Health\u2010Related Quality of Life in Patients With Cystinuria on Tiopronin Therapy"},"content":{"rendered":"\n\n\n\n<section class=\"o-hero-section o-hero--banner o-hero--blue o-hero--cropped\">\n    <img decoding=\"async\" width=\"1921\" height=\"1081\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/11\/kidney-stones_header.png\" class=\"a-img a-img--right h-full\" alt=\"Hero Section Background Image\" loading=\"lazy\" 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href=\"https:\/\/clleancode.top\/travere-redesign\/\">Home<\/a><\/span><\/span><\/nav>            <\/div>\n            <h1 class=\"a-heading a-heading--h1 h-white\">Assessment of Health\u2010Related Quality of Life in Patients With Cystinuria on Tiopronin Therapy<\/h1>                    <\/div>\n    <\/div>\n<\/section>\n\n\r\n\t<section style=\"margin-top:calc(-150px * var(--scale));\" class=\"section-container wp-block-grizzly-section-container\">\r\n\t\t\t\t<div class=\"container\">\r\n\t\t\t\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\">\n<div class=\"info-block info-block-publication search__container-publication search__container\">\n\t<div class=\"info-block-top\">\n\t\t<div>\n\t\t\t\t\t\t\t<div class=\"info-block-type\"><i class=\"icon2-journal\"><\/i> Journal article<\/div>\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"info-block-type\">\n\t\t\t\t\t<i class=\"icon2-calendar\"><\/i> Published on December 13, 2019\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t<p>Topics: <\/p>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">Nephrology<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">Cystinuria<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\t<div class=\"info-block-bottom\">\n\t\t\t\t\t<div class=\"info-block-box\">\n\t\t\t\tContributors:<br \/><span>Modersitzki F, Goldfarb DS, Goldstein RL et al.<\/span>\n\t\t\t<\/div>\n\t\t\n\t\t<div class=\"info-block-box\">\n\t\t\t\t\t\t\tName of Journal:<br \/><span>Urolithiasis<\/span><br \/><br \/><br \/>\n\t\t\t\n\t\t\t\t\t\t\t<a href=\"#\" data-url=\"https:\/\/link.springer.com\/article\/10.1007\/s00240-019-01174-6\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"btn btn-outline leaving-modal-toggle btn-leaving\" aria-label=\"View Publication\">View Publication<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"info-block-box info-block-doi\">\n\t\t\t\tDOI:<br \/><span>10.1007\/s00240-019-01174-6<\/span>\n\t\t\t<\/div>\n\t\t\n\t\t<div class=\"info-block-share\">Share:\n\t\t\t<span>\n\t\t\t\t\t<a href=\"https:\/\/twitter.com\/intent\/tweet?url=https%3A%2F%2Fclleancode.top%2Ftravere-redesign%2Fpublications%2Fquality-of-life-cystinuria-tiopronin-therapy%2F&#038;text=Assessment+of+Health%E2%80%90Related+Quality+of+Life+in+Patients+With+Cystinuria+on+Tiopronin+Therapy\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"icon2-x\" aria-label=\"Share on Twitter\"><\/a> \n\t<a href=\"https:\/\/www.linkedin.com\/shareArticle?url=https%3A%2F%2Fclleancode.top%2Ftravere-redesign%2Fpublications%2Fquality-of-life-cystinuria-tiopronin-therapy%2F&#038;title=Assessment+of+Health%E2%80%90Related+Quality+of+Life+in+Patients+With+Cystinuria+on+Tiopronin+Therapy\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"icon2-linkedin-2\" aria-label=\"Share on LinkedIn\"><\/a> \n\t<a 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For more information, review the <a href=\"https:\/\/travere.com\/privacy\/\" target=\"_blank\">Travere privacy policies<\/a>.<\/span><\/label><\/span><\/span><\/span>\n  <\/div>\n  <div class=\"form-group text-right\">\n    <input class=\"wpcf7-form-control wpcf7-submit has-spinner btn\" id=\"request-submit\" type=\"submit\" value=\"Yes, continue\" \/>\n  <\/div>\n<\/div><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div> <\/div>\n\n\t\t<\/div>\r\n\t<\/section>\r\n\t\n\n\r\n\t<section class=\"section-container wp-block-grizzly-section-container\">\r\n\t\t\t\t<div class=\"container\">\r\n\t\t\t\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading has-text-align-center has-heading-4-font-size\" id=\"h-summary\" style=\"margin-top:calc(60px * var(--scale));margin-bottom:calc(30px * var(--scale))\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-teal-color\"><span class=\"fw-600\">Summary<\/span><\/mark><\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-heading-5-font-size\" id=\"h-a-survey-study-assessed-the-quality-of-life-qol-in-patients-with-cystinuria-receiving-tiopronin-compared-to-those-not-receiving-tiopronin-1\"><span class=\"fw-600\">A survey study assessed the quality of life (QoL) in patients with cystinuria receiving tiopronin compared to those not receiving tiopronin<sup>1<\/sup><\/span><\/h3>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-heading-5-font-size\" id=\"h-background\"><br><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Background<\/mark><\/span><\/h4>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Cystinuria is a rare genetic disorder leading to recurrent kidney stones.<sup>2<\/sup> These stones affect daily and professional activities and reduce quality of life (QoL).<sup>3,4<\/sup><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Management of cystinuria includes lifestyle adaptations, such as increased fluid intake, as well as alkalinization of urine and prescription of cystine-binding thiol drugs (CBTD) such as tiopronin.<sup>1,5<\/sup> Tiopronin in cystinuria reduces stone formation by lowering the cystine level in urine to increase solubility.<sup>5<\/sup><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>There is limited evidence on the effect of tiopronin in cystinuria on health-related quality of life (HRQoL).<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-heading-5-font-size\" id=\"h-aim\"><br><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Aim<\/mark><\/span><\/h4>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The researchers investigated the impact of tiopronin in cystinuria on HRQoL.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-heading-5-font-size\" id=\"h-approach\"><br><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Approach<\/mark><\/span><\/h4>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>A survey was mailed to patients with cystinuria who were enrolled in two registries<sup>1<\/sup>:<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li>Patients receiving tiopronin from the Thiola\u00ae Total Care Hub registry<\/li>\n\n\n\n<li>Patients not receiving tiopronin from the Cystinuria Contact Registry at New York University School of Medicine<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The survey included the following<sup>1<\/sup>:<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li>Kidney stone experience<\/li>\n\n\n\n<li>The short form-36 version 2 (SF-36v2) generic HRQoL questionnaire<\/li>\n\n\n\n<li>The Wisconsin Stone QoL disease-specific questionnaire (WISQOL)<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Information on treatment and underlying stone disease was collected.<sup>1 <\/sup>Analysis accounted for the time between respondents\u2019 last stone events and their HRQoL assessments.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-heading-5-font-size\" id=\"h-findings\"><br><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Findings<\/mark><\/span><\/h4>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">In total, there were 312 respondents to the survey with 267 (85.6%) receiving tiopronin and 45 (14.6%) not receiving tiopronin<sup>1<\/sup><\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The tiopronin-receiving group had more severe cystinuria.<sup>1<\/sup> They had treatment with extracorporeal shock wave lithotripsy and higher<sup>1<\/sup>:<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li>Mean numbers of kidney stone events<\/li>\n\n\n\n<li>Related hospitalizations<\/li>\n\n\n\n<li>Surgeries<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Endocrine, musculoskeletal, neurologic, and skin comorbidities showed statistically significant differences between the groups.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Use of pain medications was similar between the groups.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">Patients with cystinuria receiving tiopronin had better HRQoL measured by both the SF-36v2 and WISQOL<sup>1<\/sup><\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Both groups had SF-36v2 scores below the US normative mean (score &lt;50).<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Scores for the SF-36v2 questionnaire showed better HRQoL in patients receiving tiopronin compared with those who did not.<sup>1<\/sup> Significant differences were seen for all domains except physical functioning.<sup>1<\/sup> For the tiopronin and non-tiopronin groups, respectively, the scores were<sup>1<\/sup>:<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li><span class=\"fw-600\">Role physical:<\/span> 47.2 versus 43.9 (<em>P<\/em>&lt;0.001)<\/li>\n\n\n\n<li><span class=\"fw-600\">Bodily pain:<\/span> 46.3 versus 42.3 (<em>P<\/em>&lt;0.001)<\/li>\n\n\n\n<li><span class=\"fw-600\">General health:<\/span> 45.1 versus 42.3 (<em>P<\/em>&lt;0.001)<\/li>\n\n\n\n<li><span class=\"fw-600\">Vitality:<\/span> 48.2 versus 45.3 (<em>P<\/em>&lt;0.001)<\/li>\n\n\n\n<li><span class=\"fw-600\">Social functioning:<\/span> 47.6 versus 43.9 (<em>P<\/em>&lt;0.001)<\/li>\n\n\n\n<li><span class=\"fw-600\">Role emotional:<\/span> 47.7 versus 45.3 (<em>P<\/em>&lt;0.001)<\/li>\n\n\n\n<li><span class=\"fw-600\">Physical functioning:<\/span> 49.3 versus 49.2 (<em>P<\/em>=0.359)<\/li>\n\n\n\n<li><span class=\"fw-600\">Physical component score:<\/span> 49.5 versus 47.5 (<em>P<\/em>&lt;0.001)<\/li>\n\n\n\n<li><span class=\"fw-600\">Mental component score:<\/span> 46.9 versus 44.4 (<em>P<\/em>&lt;0.001)<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Despite fewer respondents and unequal variances, the WISQOL questionnaire also showed better HRQoL in patients receiving tiopronin compared with those who did not, with the following scores, respectively<sup>1<\/sup>:<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li><span class=\"fw-600\">Social impact:<\/span> 77.6 versus 69.7 (<em>P<\/em>&lt;0.001)<\/li>\n\n\n\n<li><span class=\"fw-600\">Emotional impact:<\/span> 68.3 versus 60.0 (<em>P<\/em>&lt;0.001)<\/li>\n\n\n\n<li><span class=\"fw-600\">Disease impact:<\/span> 65.8 versus 59.3 (<em>P<\/em>&lt;0.001)<\/li>\n\n\n\n<li><span class=\"fw-600\">Vitality impact:<\/span> 67.5 versus 58.3 (<em>P<\/em>&lt;0.001)<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>For both questionnaires, worse scores were associated with shorter time since the last stone event and the presence of more comorbidities.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-heading-5-font-size\" id=\"h-key-takeaway\"><br><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Key takeaway<\/mark><\/span><\/h4>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Patients with cystinuria who were receiving tiopronin had better QoL than patients not receiving tiopronin.<sup>1<\/sup> This observation may help inform clinical management when considering pharmacological treatment or surgery.<sup>1<\/sup><br><br><br><br><br><\/p>\n\n\n\n<div class=\"newsletter\">\n\t<div class=\"newsletter-icon\">\n\t\t<span class=\"icon2-newsletter\"><\/span>\n\t<\/div>\n\t<div class=\"newsletter-text\">\n\t\t<p><strong>Sign up<\/strong> to receive scientific updates<br \/>\nfor healthcare professionals<br \/>\nfrom Travere Therapeutics.<\/p>\n\t<\/div>\n\t<div class=\"newsletter-form\">\n\t\t<script type=\"text\/javascript\">\n\/* 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\t\t\t\t\t2022\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/urine-cystine-quantification-binding-thiol-drugs\/\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: Accurate 24\u2010h Urine Cystine Quantification for Patients on Cystine\u2010Binding Thiol Drugs\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"swiper-progressbar\"><\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"publication-related-grid search-items__grid search__container\" id=\"search__container\" style=\"display: flex;\">\n\t\t\t\t<article class=\"m-card  \" aria-label=\"Publication card: Accurate 24\u2010h Urine Cystine Quantification for Patients on Cystine\u2010Binding Thiol Drugs\">\n\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/urine-cystine-quantification-binding-thiol-drugs\/\"  aria-label=\"View publication: Accurate 24\u2010h Urine Cystine Quantification for Patients on Cystine\u2010Binding Thiol Drugs\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1921\" height=\"1081\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/11\/kidney-stones_header.png\" class=\"a-img\" alt=\"Accurate 24\u2010h Urine Cystine Quantification for Patients on Cystine\u2010Binding Thiol Drugs\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/11\/kidney-stones_header.png 1921w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/11\/kidney-stones_header-300x169.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/11\/kidney-stones_header-1024x576.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/11\/kidney-stones_header-768x432.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/11\/kidney-stones_header-1536x864.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/11\/kidney-stones_header-290x163.webp 290w\" sizes=\"auto, (max-width: 1921px) 100vw, 1921px\" \/>\t\t\t\t\t\t\t<\/a>\n\t\t\t<div class=\"m-card__info\">\n\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t<span class=\"a-tag h-blue\">\n\t\t\t\t\t\t<i class=\"icon4 icon4-publication\"><\/i> Publication\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"a-tag h-blue\">Nephrology<\/span><span class=\"a-tag h-blue\">Cystinuria<\/span>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t<div class=\"m-card__text\">\n\t\t\t\t<p class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\tAccurate 24\u2010h Urine Cystine Quantification for Patients on Cystine\u2010Binding Thiol Drugs\t\t\t\t<\/p>\n\t\t\t\t<p class=\"a-text a-text--m h-ultra-dark-blue\">\n\t\t\t\t\t<em>Urolithiasis<\/em> \n\t\t\t\t\t &#8211; \t\t\t\t\t2022\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/urine-cystine-quantification-binding-thiol-drugs\/\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: Accurate 24\u2010h Urine Cystine Quantification for Patients on Cystine\u2010Binding Thiol Drugs\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t\t<\/div>\n\t\t<div class=\"publication-related-btn\">\n\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/\" class=\"a-btn a-btn--primary\" aria-label=\"See more\">See more<\/a>\n\t\t<\/div>\n\t<\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-footnotes\" style=\"margin-bottom:calc(30px * var(--scale))\"><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Footnotes<\/mark><\/span><\/h5>\n\n\n\n<p class=\"has-small-font-size\" style=\"margin-bottom:calc(30px * var(--scale))\">THIOLA (tiopronin) is a reducing and complexing thiol indicated, in combination with high fluid intake, alkali, and diet modification, for the prevention of cystine stone formation in adults and pediatric patients 20 kg and greater with severe homozygous cystinuria, who are not responsive to these measures alone.<\/p>\n\n\n\n<p class=\"has-small-font-size\" style=\"margin-bottom:calc(30px * var(--scale))\">CBTD, cystine-binding thiol drug; HRQoL, health-related quality of life; QoL, quality of life; SF-36v2, short form-36 version 2; WISQOL, Wisconsin Stone quality of life questionnaire.<\/p>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ol class=\"wp-block-list\">\n<li class=\"has-small-font-size\">Modersitzki F et al. <em>Urolithiasis<\/em>. 2020;48(4):313-320.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Streeper NM et al. <em>J Endourol<\/em>. 2017;31:S48-S53.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Penniston KL and Nakada SY. <em>Curr Opin Urol<\/em>. 2016;26:50-55.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Parr JM et al. <em>BJU Int<\/em>. 2015;116(suppl 3):31-35.<\/li>\n\n\n\n<li class=\"has-small-font-size\"><a href=\"https:\/\/thiolaec.com\/sites\/default\/files\/pdfs\/nda\/Thiola_PI.pdf\" target=\"_blank\" rel=\"noreferrer noopener\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-teal-color\"><span class=\"text-decoration-underline\">Thiola\u00ae (tiopronin). Prescribing Information. San Antonio, TX: Mission Pharmacal Company. 01\/2021.<\/span><\/mark><\/a><\/li>\n<\/ol>\n<\/div>\n\n\n<p class=\"has-text-align-right\" style=\"margin-top:calc(30px * var(--scale));margin-bottom:calc(300px * var(--scale))\">MA-DS-24-0047 | December 2024<\/p>\n<\/div>\n\n\t\t<\/div>\r\n\t<\/section>\r\n\t","protected":false},"featured_media":5194,"template":"","meta":{"inline_featured_image":false,"header_bg_color":"transparent","header_fixed":true,"post_description":"","post_download_link":"","journal_link":"","pdf_file_link":""},"product":[143,10],"therapeutic_area":[97],"disease_area":[194],"study_registry":[],"study_type":[182,183],"resource_type":[177,180],"class_list":["post-5334","publication","type-publication","status-publish","has-post-thumbnail","hentry","product-th","product-thec","therapeutic_area-neph","disease_area-cystinuria","study_type-observational","study_type-rwe","resource_type-publication","resource_type-summary"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.9 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Quality of Life in Patients with Cystinuria Receiving Tiopronin | Travere Medical Affairs<\/title>\n<meta name=\"description\" content=\"Learn more about the impact of tiopronin in cystinuria on patient quality of life scores. 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