{"id":5053,"date":"2024-10-28T18:00:03","date_gmt":"2024-10-28T18:00:03","guid":{"rendered":"https:\/\/medicalaffairs.travere.com\/?post_type=publication&#038;p=5053"},"modified":"2025-09-30T23:50:10","modified_gmt":"2025-09-30T23:50:10","slug":"protective-mechanism-sparsentan-chronic-kidney-disease-models","status":"publish","type":"publication","link":"https:\/\/clleancode.top\/travere-redesign\/publications\/protective-mechanism-sparsentan-chronic-kidney-disease-models\/","title":{"rendered":"Mechanism of Protective Actions of Sparsentan in the Kidney: Lessons From Studies in Models of Chronic Kidney Disease"},"content":{"rendered":"\n\n\n\n<section class=\"o-hero-section o-hero--banner o-hero--blue o-hero--cropped\">\n    <img decoding=\"async\" width=\"1920\" height=\"1080\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header.png\" class=\"a-img a-img--right h-full\" alt=\"Hero Section Background Image\" 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         <div class=\"m-breadcrumb\">\n                <nav class=\"breadcrumbs\" aria-label=\"breadcrumb\"><span><span><a href=\"https:\/\/clleancode.top\/travere-redesign\/\">Home<\/a><\/span><\/span><\/nav>            <\/div>\n            <h1 class=\"a-heading a-heading--h1 h-white\">Mechanism of Protective Actions of Sparsentan in the Kidney: Lessons From Studies in Models of Chronic Kidney Disease<\/h1>                    <\/div>\n    <\/div>\n<\/section>\n\n\r\n\t<section style=\"margin-top:calc(-150px * var(--scale));\" class=\"section-container wp-block-grizzly-section-container\">\r\n\t\t\t\t<div class=\"container\">\r\n\t\t\t\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\">\n<div class=\"info-block info-block-publication search__container-publication search__container\">\n\t<div class=\"info-block-top\">\n\t\t<div>\n\t\t\t\t\t\t\t<div class=\"info-block-type\"><i class=\"icon2-journal\"><\/i> Journal article<\/div>\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"info-block-type\">\n\t\t\t\t\t<i class=\"icon2-calendar\"><\/i> Published on May 29, 2024\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t<p>Topics: <\/p>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">Nephrology<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">FSGS<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">IgAN<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\t<div class=\"info-block-bottom\">\n\t\t\t\t\t<div class=\"info-block-box\">\n\t\t\t\tContributors:<br \/><span>Kohan DE, Bedard PW, Jenkinson C et al.<\/span>\n\t\t\t<\/div>\n\t\t\n\t\t<div class=\"info-block-box\">\n\t\t\t\t\t\t\tName of Journal:<br \/><span>Clinical Science<\/span><br \/><br \/><br \/>\n\t\t\t\n\t\t\t\t\t\t\t<a href=\"#\" data-url=\"https:\/\/www.pubmed.ncbi.nlm.nih.gov\/38808486\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"btn btn-outline leaving-modal-toggle btn-leaving\" aria-label=\"View Publication\">View Publication<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"info-block-box info-block-doi\">\n\t\t\t\tDOI:<br \/><span>10.1042\/CS20240249<\/span>\n\t\t\t<\/div>\n\t\t\n\t\t<div class=\"info-block-share\">Share:\n\t\t\t<span>\n\t\t\t\t\t<a href=\"https:\/\/twitter.com\/intent\/tweet?url=https%3A%2F%2Fclleancode.top%2Ftravere-redesign%2Fpublications%2Fprotective-mechanism-sparsentan-chronic-kidney-disease-models%2F&#038;text=Mechanism+of+Protective+Actions+of+Sparsentan+in+the+Kidney%3A+Lessons+From+Studies+in+Models+of+Chronic+Kidney+Disease\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"icon2-x\" aria-label=\"Share on Twitter\"><\/a> \n\t<a 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For more information, review the <a href=\"https:\/\/travere.com\/privacy\/\" target=\"_blank\">Travere privacy policies<\/a>.<\/span><\/label><\/span><\/span><\/span>\n  <\/div>\n  <div class=\"form-group text-right\">\n    <input class=\"wpcf7-form-control wpcf7-submit has-spinner btn\" id=\"request-submit\" type=\"submit\" value=\"Yes, continue\" \/>\n  <\/div>\n<\/div><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div> <\/div>\n\n\t\t<\/div>\r\n\t<\/section>\r\n\t\n\n\r\n\t<section style=\"padding-top:calc(30px * var(--scale));\" class=\"section-container wp-block-grizzly-section-container\">\r\n\t\t\t\t<div class=\"container\">\r\n\t\t\t\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\">\n<div class=\"event-video\" id=\"video\">\n\t\t\t<p class=\"has-heading-3-font-size\">Sparsentan Mode of Action<\/p>\n\t\t\n\t<a href=\"#\" class=\"event-video--img\" style=\"background-image: url('https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Kohan-PDP-video_thumbnail-scaled.webp');\">\n\t\t<span class=\"icon2-play\" aria-hidden=\"true\"><\/span>\n\t<\/a>\n\t\n\t<div class=\"event-video--vimeo\"><\/div>\n\t\n\t<\/div>\n\n<script src=\"https:\/\/player.vimeo.com\/api\/player.js\"><\/script>\n<script>\n\tdocument.addEventListener(\"DOMContentLoaded\", function() {\n\t\tconst imgLink = document.querySelector(\".event-video--img\");\n\t\tconst vimeoDiv = document.querySelector(\".event-video--vimeo\");\n\t\tlet iframeExists = false;\n\t\tlet player;\n\n\t\timgLink.addEventListener(\"click\", function(event) {\n\t\t\tevent.preventDefault();\n\n\t\t\tif (!iframeExists) {\n\t\t\t\tconst iframe = document.createElement(\"iframe\");\n\t\t\t\tiframe.src = \"https:\/\/player.vimeo.com\/video\/1079845339\";\n\t\t\t\tiframe.frameBorder = \"0\";\n\t\t\t\tiframe.allow = \"autoplay; fullscreen\";\n\t\t\t\tiframe.allowFullscreen = true;\n\t\t\t\tvimeoDiv.appendChild(iframe);\n\t\t\t\t\n\t\t\t\tplayer = new Vimeo.Player(iframe);\n\t\t\t\tplayer.play();\n\t\t\t\tiframeExists = true;\n\t\t\t}\n\n\t\t\tvimeoDiv.style.display = \"block\";\n\t\t\timgLink.style.display = \"none\";\n\t\t});\n\n\t\tvimeoDiv.addEventListener(\"click\", function() {\n\t\t\tconst iframe = vimeoDiv.querySelector(\"iframe\");\n\t\t\tiframe.contentWindow.postMessage('{\"method\":\"play\"}', 'https:\/\/player.vimeo.com\/video\/1079845339');\n\t\t});\n\t});\n<\/script>\n\n\n<h2 class=\"wp-block-heading has-text-align-center has-heading-4-font-size\" id=\"h-summary\" style=\"margin-top:calc(60px * var(--scale));margin-bottom:calc(30px * var(--scale))\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-teal-color\">Summary<\/mark><\/strong><\/h2>\n\n\n\n<div class=\"conclusions\">\n\t\t\t<p class=\"has-heading-5-font-size\">Endothelin-1 (ET-1) and angiotensin II (Ang II)<\/p>\n\t\n\t<div class=\"conclusions-inner\">\n\t\t<div class=\"conclusions-left\">\n\t\t\t\t\t\t\t<p>ET-1 and Ang II are important disease mediators in chronic progressive kidney disease such as IgA nephropathy and focal segmental glomerulosclerosis (FSGS)<sup>1<sup \/><\/p>\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"conclusions-list\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"conclusions-list-item\">ET-1 and Ang II are present throughout the kidney and are strongly implicated in renal pathophysiology<sup>1-3<sup \/><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"conclusions-list-item\">They have similar functions within the kidney and contribute to actions such as vasoconstriction, inflammation, and cellular proliferation<sup>1,2,4<\/sup><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"conclusions-list-item\">Together, ET-1 and Ang II upregulate each other and exert an additive effect, driving ongoing kidney damage<sup>1,5,6<\/sup><\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t<div class=\"conclusions-right\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"2729\" height=\"2641\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Zoom-in-on-kidney_image.png\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Zoom-in-on-kidney_image.png 2729w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Zoom-in-on-kidney_image-300x290.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Zoom-in-on-kidney_image-1024x991.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Zoom-in-on-kidney_image-768x743.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Zoom-in-on-kidney_image-1536x1486.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Zoom-in-on-kidney_image-2048x1982.webp 2048w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Zoom-in-on-kidney_image-290x281.webp 290w\" sizes=\"auto, (max-width: 2729px) 100vw, 2729px\" \/>\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<p>ET-1 and Ang II are present throughout the kidney<\/p>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"conclusions\">\n\t\t\t<p class=\"has-heading-5-font-size\">Class and structure of sparsentan<\/p>\n\t\n\t<div class=\"conclusions-inner\">\n\t\t<div class=\"conclusions-left\">\n\t\t\t\t\t\t\t<p>Sparsentan is a Dual Endothelin Angiotensin Receptor Antagonist (DEARA), with nephroprotective effects<sup>1<\/sup><br \/>\r\n<br \/>\r\nThe sparsentan molecule consists of<sup>1<\/sup>:<br \/>\r\n<\/p>\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"conclusions-list\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"conclusions-list-item\">A moiety that inhibits the endothelin type A receptor (ET<sub>A<\/sub>R)<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"conclusions-list-item\">A moiety that inhibits the angiotensin II subtype 1 receptor (AT<sub>1<\/sub>R)<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t<div class=\"conclusions-right\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"2292\" height=\"1672\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Target-ET1R-AT1R_image.png\" class=\"attachment-full size-full\" alt=\"ET1R AT1R targeting\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Target-ET1R-AT1R_image.png 2292w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Target-ET1R-AT1R_image-300x219.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Target-ET1R-AT1R_image-1024x747.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Target-ET1R-AT1R_image-768x560.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Target-ET1R-AT1R_image-1536x1121.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Target-ET1R-AT1R_image-2048x1494.webp 2048w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Target-ET1R-AT1R_image-290x212.webp 290w\" sizes=\"auto, (max-width: 2292px) 100vw, 2292px\" \/>\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<p>The molecular structure of sparsentan targets ET<sub>A<\/sub>R and AT<sub>1<\/sub>R<\/p>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading has-heading-5-font-size\" id=\"h-protective-effects-of-sparsentan\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\"><span class=\"fw-600\">Protective effects of sparsentan<\/span><\/mark><\/h3>\n\n\n\n<div style=\"height:22px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Sparsentan targets glomerular injury and slows kidney function decline through several protective effects<sup>1,7<\/sup><br><br>Preclinical data support the direct cellular, and resulting structural, actions of sparsentan<sup>1*<\/sup><\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><thead><tr><th class=\"has-text-align-left\" data-align=\"left\"><span class=\"fw-600\">In IgA nephropathy<\/span><\/th><th class=\"has-text-align-left\" data-align=\"left\"><span class=\"fw-600\">In FSGS<\/span><\/th><\/tr><\/thead><tbody><tr><td class=\"has-text-align-left\" data-align=\"left\">Anti-inflammatory<sup>8-11*<\/sup><\/td><td class=\"has-text-align-left\" data-align=\"left\">Podocyte-protective<sup>13,14*<\/sup><\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">Anti-proliferative<sup>8,9,11*<\/sup><\/td><td class=\"has-text-align-left\" data-align=\"left\">Glycocalyx-protective<sup>14*<\/sup><\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">Anti-fibrotic<sup>10,11*<\/sup><\/td><td class=\"has-text-align-left\" data-align=\"left\">Glomerular vasodilation<sup>13,14*<\/sup><\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">Anti-proteinuric<sup>12<\/sup><\/td><td class=\"has-text-align-left\" data-align=\"left\">Anti-fibrotic<sup>13*<\/sup><\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\"><\/td><td class=\"has-text-align-left\" data-align=\"left\">Anti-inflammatory<sup>15*<\/sup><\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\"><\/td><td class=\"has-text-align-left\" data-align=\"left\">Anti-proteinuric<sup>16,17<\/sup><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center\"><sup>*<\/sup>These effects are based on pre-clinical animal modeling data.<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\t<div class=\"feature-block \">\n\t\t\t\t\t\t\t<div class=\"feature-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"has-heading-5-font-size\">Resources<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\n\t<div class=\"feature-block feature-block--center\">\n\t\t\t\t\t\t\t<div class=\"m-card\">\n\t\t\t\t\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"890\" height=\"505\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/IgAN-infographic-thumbnail.webp\" class=\"a-img\" alt=\"IgAN: Explore the sparsentan mode of action \" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/IgAN-infographic-thumbnail.webp 890w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/IgAN-infographic-thumbnail-300x170.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/IgAN-infographic-thumbnail-768x436.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/IgAN-infographic-thumbnail-290x165.webp 290w\" sizes=\"auto, (max-width: 890px) 100vw, 890px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"m-card__info\">\n\t\t\t\t\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag a-tag--blue\">Downloadable Resource<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">Nephrology<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t\t\t\t\t<div class=\"m-card__text\">\n\t\t\t\t\t\t\t\t<h4 class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\t\t\t\t\tIgAN: Explore the sparsentan mode of action \t\t\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/06\/IgAN-PDF-Travere-Therapeutics-2025-Sparsentan-in-IgAN.pdf\" target=\"_blank\" rel=\"noopener\" class=\"a-btn a-btn--secondary--blue\">\n\t\t\t\t\t\t\t\t\t\t<span>View<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"m-card\">\n\t\t\t\t\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"3584\" height=\"2020\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Screenshot-2025-04-17-at-22.31.29.png\" class=\"a-img\" alt=\"FSGS: Explore the sparsentan mode of action\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Screenshot-2025-04-17-at-22.31.29.png 3584w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Screenshot-2025-04-17-at-22.31.29-300x169.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Screenshot-2025-04-17-at-22.31.29-1024x577.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Screenshot-2025-04-17-at-22.31.29-768x433.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Screenshot-2025-04-17-at-22.31.29-1536x866.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Screenshot-2025-04-17-at-22.31.29-2048x1154.webp 2048w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/10\/Screenshot-2025-04-17-at-22.31.29-290x163.webp 290w\" sizes=\"auto, (max-width: 3584px) 100vw, 3584px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"m-card__info\">\n\t\t\t\t\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag a-tag--blue\">Downloadable Resource<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">Nephrology<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t\t\t\t\t<div class=\"m-card__text\">\n\t\t\t\t\t\t\t\t<h4 class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\t\t\t\t\tFSGS: Explore the sparsentan mode of action\t\t\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/06\/FSGS-PDF-Travere-Therapeutics-2025-Sparsentan-in-FSGS.pdf\" target=\"_blank\" rel=\"noopener\" class=\"a-btn a-btn--secondary--blue\">\n\t\t\t\t\t\t\t\t\t\t<span>View<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\t<div class=\"feature-block feature-block--half\">\n\t\t\t\t\t\t\t<div class=\"feature-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"has-heading-5-font-size\">Conclusions<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p><p>Collectively, the protective effects of sparsentan contribute to nephroprotection in kidney disease<sup>1<sup\/><\/p>\n<ul>\n<li class=\"p1\">By blocking important disease mediators, ET-1 and Ang II, sparsentan, a DEARA, can reduce glomerular injury and help preserve kidney function<sup>1<sup\/<\/li>\n<\/ul>\n<\/p>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"feature-image\">\n\t\t\t\t\t\t\t\t\t\t\t\t<div href=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header.png\" >\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1920\" height=\"1080\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header.png\" class=\"attachment-full size-full\" alt=\"Tablets and chemical structure of sparsentan\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header.png 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-300x169.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-1024x576.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-768x432.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-1536x864.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-290x163.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer paragraph-border\"><\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer paragraph-border\"><\/div>\n\n\n\n<div class=\"newsletter\">\n\t<div class=\"newsletter-icon\">\n\t\t<span class=\"icon2-newsletter\"><\/span>\n\t<\/div>\n\t<div class=\"newsletter-text\">\n\t\t<p><strong>Sign up<\/strong> to receive scientific updates<br \/>\nfor healthcare professionals<br 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Dual Angiotensin II AT1 Receptor Blocker and Endothelin ETA Receptor Antagonist, Treatment of Focal Segmental Glomerulosclerosis, Treatment of IgA Nephropathy\">\n\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/dual-antagonist-sparsentan-igan-fsgs-treatment\/\"  aria-label=\"View publication: Sparsentan. Dual Angiotensin II AT1 Receptor Blocker and Endothelin ETA Receptor Antagonist, Treatment of Focal Segmental Glomerulosclerosis, Treatment of IgA Nephropathy\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1920\" height=\"1080\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header.png\" class=\"a-img\" alt=\"Sparsentan. Dual Angiotensin II AT1 Receptor Blocker and Endothelin ETA Receptor Antagonist, Treatment of Focal Segmental Glomerulosclerosis, Treatment of IgA Nephropathy\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header.png 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-300x169.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-1024x576.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-768x432.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-1536x864.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-290x163.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t<\/a>\n\t\t\t<div class=\"m-card__info\">\n\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t<span class=\"a-tag h-blue\">\n\t\t\t\t\t\t<i class=\"icon4 icon4-publication\"><\/i> Publication\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"a-tag h-blue\">Nephrology<\/span><span class=\"a-tag h-blue\">FSGS<\/span><span class=\"a-tag h-blue\">IgAN<\/span>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t<div class=\"m-card__text\">\n\t\t\t\t<p class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\tSparsentan. Dual Angiotensin II AT1 Receptor Blocker and Endothelin ETA Receptor Antagonist, Treatment of Focal Segmental Glomerulosclerosis, Treatment of IgA Nephropathy\t\t\t\t<\/p>\n\t\t\t\t<p class=\"a-text a-text--m h-ultra-dark-blue\">\n\t\t\t\t\t<em>Drugs of the Future<\/em> \n\t\t\t\t\t &#8211; \t\t\t\t\t2020\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/dual-antagonist-sparsentan-igan-fsgs-treatment\/\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: Sparsentan. Dual Angiotensin II AT1 Receptor Blocker and Endothelin ETA Receptor Antagonist, Treatment of Focal Segmental Glomerulosclerosis, Treatment of IgA Nephropathy\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t<article class=\"m-card  \" aria-label=\"Publication card: Sparsentan: The First and Only Non-Immunosuppressive Therapy for the Reduction of Proteinuria in IgA Nephropathy\">\n\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/?post_type=publication&#038;p=4939\"  aria-label=\"View publication: Sparsentan: The First and Only Non-Immunosuppressive Therapy for the Reduction of Proteinuria in IgA Nephropathy\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1920\" height=\"1080\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header.png\" class=\"a-img\" alt=\"Sparsentan: The First and Only Non-Immunosuppressive Therapy for the Reduction of Proteinuria in IgA Nephropathy\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header.png 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-300x169.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-1024x576.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-768x432.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-1536x864.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-290x163.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t<\/a>\n\t\t\t<div class=\"m-card__info\">\n\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t<span class=\"a-tag h-blue\">\n\t\t\t\t\t\t<i class=\"icon4 icon4-publication\"><\/i> Publication\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"a-tag h-blue\">Nephrology<\/span><span class=\"a-tag h-blue\">IgAN<\/span>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t<div class=\"m-card__text\">\n\t\t\t\t<p class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\tSparsentan: The First and Only Non-Immunosuppressive Therapy for the Reduction of Proteinuria in IgA Nephropathy\t\t\t\t<\/p>\n\t\t\t\t<p class=\"a-text a-text--m h-ultra-dark-blue\">\n\t\t\t\t\t<em>Expert Review of Clinical Immunology<\/em> \n\t\t\t\t\t &#8211; \t\t\t\t\t2024\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/?post_type=publication&#038;p=4939\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: Sparsentan: The First and Only Non-Immunosuppressive Therapy for the Reduction of Proteinuria in IgA Nephropathy\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t<article class=\"m-card  \" aria-label=\"Publication card: Efficacy and Safety of Sparsentan Versus Irbesartan in Patients with IgA Nephropathy (PROTECT): 2-Year Results From a Randomised Active-Controlled Phase 3 Trial\">\n\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/protect-2-year-results-sparsentan-vs-irbesartan-iga-nephropathy\/\"  aria-label=\"View publication: Efficacy and Safety of Sparsentan Versus Irbesartan in Patients with IgA Nephropathy (PROTECT): 2-Year Results From a Randomised Active-Controlled Phase 3 Trial\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"478\" height=\"273\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/07\/publication-home-1.jpg\" class=\"a-img\" alt=\"Efficacy and Safety of Sparsentan Versus Irbesartan in Patients with IgA Nephropathy (PROTECT): 2-Year Results From a Randomised Active-Controlled Phase 3 Trial\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/07\/publication-home-1.jpg 478w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/07\/publication-home-1-300x171.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/07\/publication-home-1-290x166.webp 290w\" sizes=\"auto, (max-width: 478px) 100vw, 478px\" \/>\t\t\t\t\t\t\t<\/a>\n\t\t\t<div class=\"m-card__info\">\n\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t<span class=\"a-tag h-blue\">\n\t\t\t\t\t\t<i class=\"icon4 icon4-publication\"><\/i> Publication\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"a-tag h-blue\">Nephrology<\/span><span class=\"a-tag h-blue\">IgAN<\/span>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t<div class=\"m-card__text\">\n\t\t\t\t<p class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\tEfficacy and Safety of Sparsentan Versus Irbesartan in Patients with IgA Nephropathy (PROTECT): 2-Year Results From a Randomised Active-Controlled Phase 3 Trial\t\t\t\t<\/p>\n\t\t\t\t<p class=\"a-text a-text--m h-ultra-dark-blue\">\n\t\t\t\t\t<em>The Lancet<\/em> \n\t\t\t\t\t &#8211; \t\t\t\t\t2023\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/protect-2-year-results-sparsentan-vs-irbesartan-iga-nephropathy\/\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: Efficacy and Safety of Sparsentan Versus Irbesartan in Patients with IgA Nephropathy (PROTECT): 2-Year Results From a Randomised Active-Controlled Phase 3 Trial\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t\t<\/div>\n\t\t<div class=\"publication-related-btn\">\n\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/\" class=\"a-btn a-btn--primary\" aria-label=\"See more\">See more<\/a>\n\t\t<\/div>\n\t<\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-heading-5-font-size\" id=\"h-footnotes\" style=\"margin-bottom:calc(30px * var(--scale))\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Footnotes<\/mark><\/strong><\/h4>\n\n\n\n<p class=\"has-small-font-size\" style=\"margin-bottom:calc(30px * var(--scale))\">As of October 2024, sparsentan is not FDA approved for the treatment of FSGS.<\/p>\n\n\n\n<p class=\"has-small-font-size\" style=\"margin-bottom:calc(30px * var(--scale))\">Ang II, angiotensin II; AT<sub>1<\/sub>R, angiotensin II subtype 1 receptor; DEARA, Dual Endothelin Angiotensin Receptor Antagonist; ET-1, endothelin-1; ET<sub>A<\/sub>R, endothelin type A receptor; FSGS, focal segmental glomerulosclerosis; IgA, immunoglobulin A.<\/p>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ol class=\"wp-block-list\">\n<li class=\"has-small-font-size\">Kohan DE et al. <em>Clin Sci<\/em>. 2024;138(11):645-662.<\/li>\n\n\n\n<li class=\"has-small-font-size\">R\u00fcster C and Wolf G. <em>J Am Soc Nephrol<\/em>. 2011;22:1189-1199.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Kohan DE and Barton M. <em>Kidney Int<\/em>. 2014;86:896-904.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Komers R and Plotkin H. <em>Am J Physiol Regul Integr Comp Physiol<\/em>. 2016;310(10):R877-R884.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Kohno M et al. <em>Kidney Int<\/em>. 1992;42:860-866.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Chen L et al. <em>Hypertension<\/em>. 1995;26:83-88.<\/li>\n\n\n\n<li class=\"has-small-font-size\">FILSPARI\u00ae (sparsentan) Prescribing Information. San Diego, CA: Travere Therapeutics, Inc. 9\/2024.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Jenkinson C et al. Poster presented at: ISN World Congress of Nephrology; April 12-15, 2019; Melbourne, Australia. SAT-010.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Reily C et al. <em>Am J Physiol Renal Physiol<\/em>. 2024;326:F862-F875.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Nagasawa H et al. <em>Nephrol Dial Transplant<\/em>. 2024;39:1494-1503.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Jenkinson C et al. Presentation at: International Symposium on IgA Nephropathy; September 27-29, 2018; Buenos Aires, Argentina.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Rovin BH et al. <em>Lancet<\/em>. 2023;402(10417):2077-2090.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Gyarmati G et al. Presented at: 51st European Renal Association Congress 2021; June 5-8, 2021; Virtual and Berlin. \u2028<\/li>\n\n\n\n<li class=\"has-small-font-size\">Gyarmati C et al. Presented at: American Society of Nephrology Kidney Week 2022; November 3-6, 2022; Orlando, Florida. FR OR56.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Bedard PW et al. Presented at: 59th European Renal Association Congress 2022; May 19-21, 2022; Virtual and Paris.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Trachtman H et al. <em>J Am Soc Nephrol<\/em>. 2018;29(11):2745-2754.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Hogan J et al. Presented at: American Society of Nephrology Kidney Week 2022; October 23-28, 2018; San Diego. FR OR087.<\/li>\n<\/ol>\n<\/div>\n\n\n<p class=\"has-text-align-right\" style=\"margin-top:calc(30px * var(--scale));margin-bottom:calc(300px * var(--scale))\">MA-SP-24-0108 | April 2025<\/p>\n<\/div>\n\n\t\t<\/div>\r\n\t<\/section>\r\n\t","protected":false},"featured_media":4897,"template":"","meta":{"inline_featured_image":false,"header_bg_color":"transparent","header_fixed":true,"post_description":"","post_download_link":"","journal_link":"","pdf_file_link":""},"product":[78],"therapeutic_area":[97],"disease_area":[186,174],"study_registry":[],"study_type":[181],"resource_type":[179,177,180,178],"class_list":["post-5053","publication","type-publication","status-publish","has-post-thumbnail","hentry","product-spa","therapeutic_area-neph","disease_area-fsgs","disease_area-igan","study_type-review","resource_type-infographic","resource_type-publication","resource_type-summary","resource_type-video"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.9 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Mechanism of the Protective Actions of Sparsentan in Chronic Kidney Diseases | Travere Medical Affairs<\/title>\n<meta name=\"description\" content=\"Learn more about the mechanisms behind the protective actions of sparsentan in chronic kidney diseases. 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