{"id":4974,"date":"2020-10-03T20:02:00","date_gmt":"2020-10-03T20:02:00","guid":{"rendered":"https:\/\/medicalaffairs.travere.com\/?post_type=publication&#038;p=4974"},"modified":"2025-09-30T23:59:40","modified_gmt":"2025-09-30T23:59:40","slug":"dual-antagonist-sparsentan-igan-fsgs-treatment","status":"publish","type":"publication","link":"https:\/\/clleancode.top\/travere-redesign\/publications\/dual-antagonist-sparsentan-igan-fsgs-treatment\/","title":{"rendered":"Sparsentan. Dual Angiotensin II AT1 Receptor Blocker and Endothelin ETA Receptor Antagonist, Treatment of Focal Segmental Glomerulosclerosis, Treatment of IgA Nephropathy"},"content":{"rendered":"\n\n\n\n<section class=\"o-hero-section o-hero--banner o-hero--blue o-hero--cropped\">\n    <img decoding=\"async\" width=\"1920\" height=\"1080\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header.png\" class=\"a-img a-img--right h-full\" alt=\"Hero Section Background Image\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header.png 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-300x169.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-1024x576.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-768x432.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-1536x864.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/tablets-sparsentan-chemical-structure_header-290x163.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>    <div class=\"container\">\n        <div class=\"m-hero-inner m-hero-inner--post\">\n            <div class=\"m-breadcrumb\">\n                <nav class=\"breadcrumbs\" aria-label=\"breadcrumb\"><span><span><a href=\"https:\/\/clleancode.top\/travere-redesign\/\">Home<\/a><\/span><\/span><\/nav>            <\/div>\n            <h1 class=\"a-heading a-heading--h1 h-white\">Sparsentan. Dual Angiotensin II AT1 Receptor Blocker and Endothelin ETA Receptor Antagonist, Treatment of Focal Segmental Glomerulosclerosis, Treatment of IgA Nephropathy<\/h1>                    <\/div>\n    <\/div>\n<\/section>\n\n\r\n\t<section style=\"margin-top:calc(-150px * var(--scale));\" class=\"section-container wp-block-grizzly-section-container\">\r\n\t\t\t\t<div class=\"container\">\r\n\t\t\t\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\">\n<div class=\"info-block info-block-publication search__container-publication search__container\">\n\t<div class=\"info-block-top\">\n\t\t<div>\n\t\t\t\t\t\t\t<div class=\"info-block-type\"><i class=\"icon2-journal\"><\/i> Journal article<\/div>\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"info-block-type\">\n\t\t\t\t\t<i class=\"icon2-calendar\"><\/i> Published on September 13, 2024\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t<p>Topics: <\/p>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">Nephrology<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">FSGS<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">IgAN<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\t<div class=\"info-block-bottom\">\n\t\t\t\t\t<div class=\"info-block-box\">\n\t\t\t\tContributors:<br \/><span>Trachtman H, Hogan JJ, Tesar V et\u00a0al.<\/span>\n\t\t\t<\/div>\n\t\t\n\t\t<div class=\"info-block-box\">\n\t\t\t\t\t\t\tName of Journal:<br \/><span>Drugs of the Future<\/span><br \/><br \/><br \/>\n\t\t\t\n\t\t\t\t\t\t\t<a href=\"#\" data-url=\"https:\/\/access.portico.org\/Portico\/auView?auId=ark:%2F27927%2Fpjbf78x5c22\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"btn btn-outline leaving-modal-toggle btn-leaving\" aria-label=\"View Publication\">View Publication<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"info-block-box info-block-doi\">\n\t\t\t\tDOI:<br \/><span>http:\/\/dx.doi.org\/10.1358\/dof.2020.45.2.3058863<\/span>\n\t\t\t<\/div>\n\t\t\n\t\t<div class=\"info-block-share\">Share:\n\t\t\t<span>\n\t\t\t\t\t<a href=\"https:\/\/twitter.com\/intent\/tweet?url=https%3A%2F%2Fclleancode.top%2Ftravere-redesign%2Fpublications%2Fdual-antagonist-sparsentan-igan-fsgs-treatment%2F&#038;text=Sparsentan.+Dual+Angiotensin+II+AT1+Receptor+Blocker+and+Endothelin+ETA+Receptor+Antagonist%2C+Treatment+of+Focal+Segmental+Glomerulosclerosis%2C+Treatment+of+IgA+Nephropathy\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"icon2-x\" aria-label=\"Share on Twitter\"><\/a> \n\t<a href=\"https:\/\/www.linkedin.com\/shareArticle?url=https%3A%2F%2Fclleancode.top%2Ftravere-redesign%2Fpublications%2Fdual-antagonist-sparsentan-igan-fsgs-treatment%2F&#038;title=Sparsentan.+Dual+Angiotensin+II+AT1+Receptor+Blocker+and+Endothelin+ETA+Receptor+Antagonist%2C+Treatment+of+Focal+Segmental+Glomerulosclerosis%2C+Treatment+of+IgA+Nephropathy\" target=\"_blank\" 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For more information, review the <a href=\"https:\/\/travere.com\/privacy\/\" target=\"_blank\">Travere privacy policies<\/a>.<\/span><\/label><\/span><\/span><\/span>\n  <\/div>\n  <div class=\"form-group text-right\">\n    <input class=\"wpcf7-form-control wpcf7-submit has-spinner btn\" id=\"request-submit\" type=\"submit\" value=\"Yes, continue\" \/>\n  <\/div>\n<\/div><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div> <\/div>\n\n\t\t<\/div>\r\n\t<\/section>\r\n\t\n\n\r\n\t<section class=\"section-container wp-block-grizzly-section-container\">\r\n\t\t\t\t<div class=\"container\">\r\n\t\t\t\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading has-text-align-center has-heading-4-font-size\" id=\"h-summary\" style=\"margin-top:calc(60px * var(--scale));margin-bottom:calc(30px * var(--scale))\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-teal-color\"><span class=\"fw-600\">Summary<\/span><\/mark><br><\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-heading-5-font-size\" id=\"h-clinical-development-of-sparsentan-for-iga-nephropathy-and-focal-segmental-glomerulosclerosis-fsgs-focused-on-inhibiting-the-renin-angiotensin-system-ras-and-the-endothelin-et-system-1\"><span class=\"fw-600\">Clinical development of sparsentan for IgA nephropathy and focal segmental glomerulosclerosis (FSGS) focused on inhibiting the renin-angiotensin system (RAS) and the endothelin (ET) system<sup> 1<\/sup><\/span><\/h3>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-heading-5-font-size\" id=\"h-background\"><br><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\"><span class=\"fw-600\">Background<\/span><\/mark><\/h4>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Concurrent inhibition of the renin-angiotensin system (RAS) and the endothelin (ET) system is a potential approach for the treatment of proteinuric chronic kidney disease (CKD).<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Sparsentan is a novel <span style=\"text-decoration: underline;\"><a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/protective-mechanism-sparsentan-chronic-kidney-disease-models\" target=\"_blank\" rel=\"noreferrer noopener\">dual ET and angiotensin II (Ang II) receptor antagonist<\/a><\/span> undergoing clinical development for the treatment of focal segmental glomerulosclerosis (FSGS) and IgA nephropathy.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-aim\"><br><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\"><span class=\"fw-600\">Aim<\/span><\/mark><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>This review article summarizes the role of dual ET and Ang II inhibition in CKD, and the characteristics of sparsentan, as well as the rationale for its use in IgA nephropathy and FSGS.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-findings\"><br><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Findings<\/mark><\/span><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">The RAS and ET systems are important to the pathophysiology of FSGS and IgA nephropathy<sup>1<\/sup><\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-left:calc(64px * var(--scale))\">\n<p><span class=\"fw-600\">RAS<\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li>Ang II stimulates vasoconstriction, cell growth, extracellular matrix development and has proinflammatory activity, leading to glomerulosclerosis and tubulointerstitial fibrosis.<sup>2,3<\/sup><\/li>\n\n\n\n<li>Aldosterone also has prosclerotic, fibrogenic, and proteinuric effects.<sup>4<\/sup><\/li>\n\n\n\n<li>Initial use of RASi, including Ang II receptor antagonists, is recommended by guidelines for management of proteinuria in FSGS and IgA nephropathy.<sup>5<\/sup><\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\"><span style=\"text-decoration: underline;\"><a href=\"https:\/\/clleancode.top\/travere-redesign\/episode\/role-of-endothelin-in-igan\/\" target=\"_blank\" rel=\"noreferrer noopener\">Endothelin-1<\/a><\/span><\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li>Endothelin-1 (ET-1) acts as a preglomerular vasoconstrictor.<sup>6<\/sup><\/li>\n\n\n\n<li>ET-1 also promotes vasoconstriction, fibrosis, and extracellular matrix production.<sup>6,7<\/sup><\/li>\n\n\n\n<li>These proinflammatory and profibrotic effects can be inhibited by endothelin receptor antagonists (ERAs).<sup>8<\/sup><\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">Rationale for dual RAAS\/ET-1 inhibition in FSGS and IgA nephropathy<\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li>Clinical benefits of dual blockade of RAS\/ET-1 with avosentan or atrasentan added to RASis have been demonstrated in diabetic nephropathy.<sup>9,10<\/sup><\/li>\n\n\n\n<li>Although RASis are recommended in both FSGS and IgA nephropathy, there remains a significant unmet need for effective and well-tolerated treatments that can reduce proteinuria and slow the loss of kidney function.<sup>1<\/sup><\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">Highlights of clinical studies of sparsentan in IgA nephropathy and FSGS<\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-left:calc(64px * var(--scale))\">\n<p><span class=\"fw-600\">DUET<\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li><span class=\"fw-600\">Design:<\/span> Phase 2, randomized, active-control, dose-escalation study of sparsentan in primary FSGS.<sup>11<\/sup> Patients were randomized to sparsentan or irbesartan for an 8-week double-blind phase, followed by an open-label extension (all patients received sparsentan).<sup>11<\/sup><\/li>\n\n\n\n<li>Learn about the <span style=\"text-decoration: underline;\"><a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/duet-phase-2-sparsentan-fsgs-efficacy-safety\/\" target=\"_blank\" rel=\"noreferrer noopener\">efficacy and safety findings from the DUET trial<\/a><\/span> and read more about partial and <span style=\"text-decoration: underline;\"><a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/proteinuria-remission-fsgs-sparsentan-duet-trial\/\" target=\"_blank\" rel=\"noreferrer noopener\">complete proteinuria remission<\/a><\/span> in the DUET Open-Label Extension Study.<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">DUPLEX<\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li><span class=\"fw-600\">Design:<\/span> Phase 3, randomized, multicenter, double-blind, active-controlled study of sparsentan versus irbesartan in patients with primary or genetic FSGS.<sup>12<\/sup> The primary efficacy endpoint was the slope of estimated glomerular filtration rate (eGFR) from Week 6 to Week 108.<sup>12<\/sup><\/li>\n\n\n\n<li>Read more about the <span style=\"text-decoration: underline;\"><a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/sparsentan-versus-irbesartan-in-focal-segmental-glomerulosclerosis\/\" target=\"_blank\" rel=\"noreferrer noopener\">efficacy and safety findings from the DUPLEX trial<\/a><\/span> and its <span style=\"text-decoration: underline;\"><a href=\"https:\/\/clleancode.top\/travere-redesign\/meetings-events\/era-congress-2025\/#duplex-low-proteinuria\" target=\"_blank\" rel=\"noreferrer noopener\"><em>post hoc <\/em>analyses of proteinuria thresholds<\/a><\/span><a href=\"https:\/\/clleancode.top\/travere-redesign\/meetings-events\/era-congress-2025\/#duplex-low-proteinuria\"> <\/a>and <span style=\"text-decoration: underline;\"><a href=\"https:\/\/clleancode.top\/travere-redesign\/posters\/duplex-proteinuria-remission-fsgs\/\" target=\"_blank\" rel=\"noreferrer noopener\">the effect on progression to kidney failure<\/a><\/span>.<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">PROTECT<\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li><span class=\"fw-600\">Design:<\/span> Phase 3, randomized, multicenter, double-blind, parallel-group, active-control study evaluating the efficacy and safety of sparsentan in IgA nephropathy in comparison to irbesartan.<sup>13<\/sup> The primary endpoint was change from baseline to Week 36 in UPCR.<sup>13<\/sup><\/li>\n\n\n\n<li>Read more about the <span style=\"text-decoration: underline;\"><a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/efficacy-and-safety-of-sparsentan-versus-irbesartan-in-patients-with-iga-nephropathy-protect-2-year-results-from-a-randomised-active-controlled-phase-3-trial-2\/\" target=\"_blank\" rel=\"noreferrer noopener\">two-year efficacy and safety findings from the PROTECT trial<\/a><\/span>.<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-key-takeaway\"><br><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Key takeaway<\/mark><\/span><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Dual RAS\/ET-1 inhibition has shown clinical benefits in studies of IgA nephropathy, and tolerability has been favorable across the studies described above.<sup>1<\/sup> Future studies may be conducted to evaluate sparsentan in other glomerular diseases.<sup>1<\/sup><br><br><br><br><br><\/p>\n\n\n\n<div class=\"newsletter\">\n\t<div class=\"newsletter-icon\">\n\t\t<span class=\"icon2-newsletter\"><\/span>\n\t<\/div>\n\t<div class=\"newsletter-text\">\n\t\t<p><strong>Sign up<\/strong> to receive scientific updates<br \/>\nfor healthcare 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For more information, review the <a href=\"https:\/\/travere.com\/privacy\/\" target=\"_blank\" rel=\"noopener\">Travere  privacy policies<\/a>.<\/p>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div id=\"invalid-newsletter\" class=\"invalid\">\n\t\t\t<div id=\"invalid-box-newsletter\">\n\t\t\t\t<span class=\"icon2-info-fill\"><\/span>\n\t\t\t<\/div>\n\t\t\t<div>\n\t\t\t\t<p><strong>Invalid email address.<\/strong><br \/>\n\t\t\t\tMake sure email is in correct format: <a href=\"\">name@example.com<\/a><\/p>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\t<div class=\"publication-related\">\n\t\t<p class=\"has-heading-4-font-size\">Related Content<\/p>\n\t\t<div class=\"publication-related-swiper-container\" style=\"display: none;\">\n\t\t\t<div class=\"swiper publicationSwiper\">\n\t\t\t\t<div class=\"swiper-wrapper\">\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"swiper-slide\">\n\t\t\t\t\t\t\t\t<article class=\"m-card  \" aria-label=\"Publication card: Efficacy and Safety of Sparsentan Versus Irbesartan in Patients with IgA Nephropathy (PROTECT): 2-Year Results From a Randomised Active-Controlled Phase 3 Trial\">\n\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/protect-2-year-results-sparsentan-vs-irbesartan-iga-nephropathy\/\"  aria-label=\"View publication: Efficacy and Safety of Sparsentan Versus Irbesartan in Patients with IgA Nephropathy (PROTECT): 2-Year Results From a Randomised Active-Controlled Phase 3 Trial\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"478\" height=\"273\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/07\/publication-home-1.jpg\" class=\"a-img\" alt=\"Efficacy and Safety of Sparsentan Versus Irbesartan in Patients with IgA Nephropathy (PROTECT): 2-Year Results From a Randomised Active-Controlled Phase 3 Trial\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/07\/publication-home-1.jpg 478w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/07\/publication-home-1-300x171.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/07\/publication-home-1-290x166.webp 290w\" sizes=\"auto, (max-width: 478px) 100vw, 478px\" \/>\t\t\t\t\t\t\t<\/a>\n\t\t\t<div class=\"m-card__info\">\n\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t<span class=\"a-tag h-blue\">\n\t\t\t\t\t\t<i class=\"icon4 icon4-publication\"><\/i> Publication\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"a-tag h-blue\">Nephrology<\/span><span class=\"a-tag h-blue\">IgAN<\/span>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t<div class=\"m-card__text\">\n\t\t\t\t<p class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\tEfficacy and Safety of Sparsentan Versus Irbesartan in Patients with IgA Nephropathy (PROTECT): 2-Year Results From a Randomised Active-Controlled Phase 3 Trial\t\t\t\t<\/p>\n\t\t\t\t<p class=\"a-text a-text--m h-ultra-dark-blue\">\n\t\t\t\t\t<em>The Lancet<\/em> \n\t\t\t\t\t &#8211; 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\t\t\t\t\t2023\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/protect-2-year-results-sparsentan-vs-irbesartan-iga-nephropathy\/\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: Efficacy and Safety of Sparsentan Versus Irbesartan in Patients with IgA Nephropathy (PROTECT): 2-Year Results From a Randomised Active-Controlled Phase 3 Trial\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t<article class=\"m-card  \" aria-label=\"Publication card: Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis\">\n\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/sparsentan-versus-irbesartan-in-focal-segmental-glomerulosclerosis\/\"  aria-label=\"View publication: Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1920\" height=\"1080\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/08\/sparsentan-clinical-trial_header.png\" class=\"a-img\" alt=\"Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/08\/sparsentan-clinical-trial_header.png 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/08\/sparsentan-clinical-trial_header-300x169.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/08\/sparsentan-clinical-trial_header-1024x576.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/08\/sparsentan-clinical-trial_header-768x432.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/08\/sparsentan-clinical-trial_header-1536x864.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/08\/sparsentan-clinical-trial_header-290x163.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t<\/a>\n\t\t\t<div class=\"m-card__info\">\n\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t<span class=\"a-tag h-blue\">\n\t\t\t\t\t\t<i class=\"icon4 icon4-publication\"><\/i> Publication\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"a-tag h-blue\">Nephrology<\/span><span class=\"a-tag h-blue\">FSGS<\/span>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t<div class=\"m-card__text\">\n\t\t\t\t<p class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\tSparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis\t\t\t\t<\/p>\n\t\t\t\t<p class=\"a-text a-text--m h-ultra-dark-blue\">\n\t\t\t\t\t<em>New England Journal of Medicine<\/em> \n\t\t\t\t\t &#8211; \t\t\t\t\t2023\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/sparsentan-versus-irbesartan-in-focal-segmental-glomerulosclerosis\/\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t<article class=\"m-card  \" aria-label=\"Publication card: DUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS\">\n\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/duet-phase-2-sparsentan-fsgs-efficacy-safety\/\"  aria-label=\"View publication: DUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1920\" height=\"1080\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/08\/sparsentan-clinical-trial_header.png\" class=\"a-img\" alt=\"DUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/08\/sparsentan-clinical-trial_header.png 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/08\/sparsentan-clinical-trial_header-300x169.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/08\/sparsentan-clinical-trial_header-1024x576.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/08\/sparsentan-clinical-trial_header-768x432.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/08\/sparsentan-clinical-trial_header-1536x864.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/08\/sparsentan-clinical-trial_header-290x163.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t<\/a>\n\t\t\t<div class=\"m-card__info\">\n\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t<span class=\"a-tag h-blue\">\n\t\t\t\t\t\t<i class=\"icon4 icon4-publication\"><\/i> Publication\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"a-tag h-blue\">Nephrology<\/span><span class=\"a-tag h-blue\">FSGS<\/span>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t<div class=\"m-card__text\">\n\t\t\t\t<p class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\tDUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS\t\t\t\t<\/p>\n\t\t\t\t<p class=\"a-text a-text--m h-ultra-dark-blue\">\n\t\t\t\t\t<em>Journal of the American Society of Nephrology<\/em> \n\t\t\t\t\t &#8211; \t\t\t\t\t2018\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/duet-phase-2-sparsentan-fsgs-efficacy-safety\/\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: DUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t\t<\/div>\n\t\t<div class=\"publication-related-btn\">\n\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/\" class=\"a-btn a-btn--primary\" aria-label=\"See more\">See more<\/a>\n\t\t<\/div>\n\t<\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-footnotes\" style=\"margin-bottom:calc(30px * var(--scale))\"><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Footnotes<\/mark><\/span><\/h5>\n\n\n\n<p class=\"has-small-font-size\">Sparsentan is not FDA-approved for the treatment of FSGS.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-small-font-size\" style=\"margin-bottom:calc(30px * var(--scale))\">Ang II, angiotensin II; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; ERA, endothelin receptor antagonist; ET, endothelin; ET-1, endothelin-1; FSGS, focal segmental glomerulosclerosis; IgA, immunoglobulin A; RAS, renin-angiotensin system; RASi, renin-angiotensin system inhibitor; UPCR, urine protein-creatinine ratio.<\/p>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ol class=\"wp-block-list\">\n<li class=\"has-small-font-size\">Trachtman H et al. <em>Drugs Future.<\/em> 2020;45(2):79.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Wennmann DO et al. <em>Semin Nephrol.<\/em> 2012;32(4):377-384.<\/li>\n\n\n\n<li class=\"has-small-font-size\">R\u00fcster C, Wolf G. <em>J Am Soc Nephrol.<\/em> 2011;22(7):1189-1199.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Sun GP et al. <em>J Am Soc Nephrol.<\/em> 2006;17(8):2193-2201.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group. <em>Kidney Int.<\/em> 2021;100(4S):S1-S276.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Kohan DE et al. <em>Physiol Rev<\/em>. 2011;91(1):1-77.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Simonson MS, Ismail-Beigi F. <em>J Biol Chem.<\/em> 2011;286(13):11003-11008.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Watson AM et al. <em>Diabetologia. <\/em>2010;53(1):192-203.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Mann JF et al. <em>J Am Soc Nephrol.<\/em> 2010;21(3):527-535.<\/li>\n\n\n\n<li class=\"has-small-font-size\">de Zeeuw D et al. <em>J Am Soc Nephrol.<\/em> 2014;25(5):1083-1093.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Trachtman H et al. <em>J Am Soc Nephrol.<\/em> 2018;29(11):2745-2754.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Rheault MN et al. <em>N Engl J Med.<\/em> 2023;389(26):2436-2445.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Heerspink HJL et al. <em>Lancet.<\/em> 2023;401(10388):1584-1594.<\/li>\n<\/ol>\n<\/div>\n\n\n<p class=\"has-text-align-right\" style=\"margin-top:calc(30px * var(--scale));margin-bottom:calc(300px * var(--scale))\">MA-SP-24-0106 | June 2025<\/p>\n<\/div>\n\n\t\t<\/div>\r\n\t<\/section>\r\n\t","protected":false},"featured_media":4897,"template":"","meta":{"inline_featured_image":false,"header_bg_color":"transparent","header_fixed":true,"post_description":"","post_download_link":"","journal_link":"https:\/\/access.portico.org\/Portico\/auView?auId=ark:%2F27927%2Fpjbf78x5c22","pdf_file_link":"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/Trachtman-DOTF-2020-Sparsentan.pdf"},"product":[78],"therapeutic_area":[97],"disease_area":[186,174],"study_registry":[193,187,175],"study_type":[181],"resource_type":[177,180],"class_list":["post-4974","publication","type-publication","status-publish","has-post-thumbnail","hentry","product-spa","therapeutic_area-neph","disease_area-fsgs","disease_area-igan","study_registry-duet","study_registry-duplex","study_registry-protect","study_type-review","resource_type-publication","resource_type-summary"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.9 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Review of Sparsentan in IgAN and FSGS | Travere Medical Affairs<\/title>\n<meta name=\"description\" content=\"Learn about the rationale for dual blockade of the RAS and ET systems and the development of sparsentan for IgAN and FSGS. 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