{"id":4904,"date":"2023-06-25T16:06:00","date_gmt":"2023-06-25T16:06:00","guid":{"rendered":"https:\/\/medicalaffairs.travere.com\/?post_type=publication&#038;p=4904"},"modified":"2025-09-30T23:57:17","modified_gmt":"2025-09-30T23:57:17","slug":"iga-nephropathy-proteinuria-kidney-function-healthcare-costs","status":"publish","type":"publication","link":"https:\/\/clleancode.top\/travere-redesign\/publications\/iga-nephropathy-proteinuria-kidney-function-healthcare-costs\/","title":{"rendered":"Impact of Proteinuria and Kidney Function Decline on Health Care Costs and Resource Utilization in Adults With IgA Nephropathy in the United States: A Retrospective Analysis"},"content":{"rendered":"\n\n\n\n<section class=\"o-hero-section o-hero--banner o-hero--blue o-hero--cropped\">\n    <img decoding=\"async\" width=\"1920\" height=\"1080\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/graph-money_header.png\" class=\"a-img a-img--right h-full\" alt=\"Hero Section Background Image\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/graph-money_header.png 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/graph-money_header-300x169.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/graph-money_header-1024x576.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/graph-money_header-768x432.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/graph-money_header-1536x864.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/graph-money_header-290x163.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>    <div class=\"container\">\n        <div class=\"m-hero-inner m-hero-inner--post\">\n            <div class=\"m-breadcrumb\">\n                <nav class=\"breadcrumbs\" aria-label=\"breadcrumb\"><span><span><a href=\"https:\/\/clleancode.top\/travere-redesign\/\">Home<\/a><\/span><\/span><\/nav>            <\/div>\n            <h1 class=\"a-heading a-heading--h1 h-white\">Impact of Proteinuria and Kidney Function Decline on Health Care Costs and Resource Utilization in Adults With IgA Nephropathy in the United States: A Retrospective Analysis<\/h1>                    <\/div>\n    <\/div>\n<\/section>\n\n\r\n\t<section style=\"margin-top:calc(-150px * var(--scale));\" class=\"section-container wp-block-grizzly-section-container\">\r\n\t\t\t\t<div class=\"container\">\r\n\t\t\t\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\">\n<div class=\"info-block info-block-publication search__container-publication search__container\">\n\t<div class=\"info-block-top\">\n\t\t<div>\n\t\t\t\t\t\t\t<div class=\"info-block-type\"><i class=\"icon2-journal\"><\/i> Journal article<\/div>\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"info-block-type\">\n\t\t\t\t\t<i class=\"icon2-calendar\"><\/i> Published on June 25, 2023\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t<p>Topics: <\/p>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">Nephrology<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">IgAN<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\t<div class=\"info-block-bottom\">\n\t\t\t\t\t<div class=\"info-block-box\">\n\t\t\t\tContributors:<br \/><span>Lerma EV, Bensink ME, Thakker KM et al.<\/span>\n\t\t\t<\/div>\n\t\t\n\t\t<div class=\"info-block-box\">\n\t\t\t\t\t\t\tName of Journal:<br \/><span>Kidney Medicine<\/span><br \/><br \/><br \/>\n\t\t\t\n\t\t\t\t\t\t\t<a href=\"#\" data-url=\"https:\/\/www.kidneymedicinejournal.org\/article\/S2590-0595(23)00111-5\/fulltext\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"btn btn-outline leaving-modal-toggle btn-leaving\" aria-label=\"View Publication\">View Publication<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"info-block-box info-block-doi\">\n\t\t\t\tDOI:<br \/><span>10.1016\/j.xkme.2023.100693<\/span>\n\t\t\t<\/div>\n\t\t\n\t\t<div class=\"info-block-share\">Share:\n\t\t\t<span>\n\t\t\t\t\t<a href=\"https:\/\/twitter.com\/intent\/tweet?url=https%3A%2F%2Fclleancode.top%2Ftravere-redesign%2Fpublications%2Figa-nephropathy-proteinuria-kidney-function-healthcare-costs%2F&#038;text=Impact+of+Proteinuria+and+Kidney+Function+Decline+on+Health+Care+Costs+and+Resource+Utilization+in+Adults+With+IgA+Nephropathy+in+the+United+States%3A+A+Retrospective+Analysis\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"icon2-x\" aria-label=\"Share on Twitter\"><\/a> \n\t<a 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For more information, review the <a href=\"https:\/\/travere.com\/privacy\/\" target=\"_blank\">Travere privacy policies<\/a>.<\/span><\/label><\/span><\/span><\/span>\n  <\/div>\n  <div class=\"form-group text-right\">\n    <input class=\"wpcf7-form-control wpcf7-submit has-spinner btn\" id=\"request-submit\" type=\"submit\" value=\"Yes, continue\" \/>\n  <\/div>\n<\/div><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div> <\/div>\n\n\t\t<\/div>\r\n\t<\/section>\r\n\t\n\n\r\n\t<section style=\"padding-top:calc(30px * var(--scale));\" class=\"section-container wp-block-grizzly-section-container\">\r\n\t\t\t\t<div class=\"container\">\r\n\t\t\t\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading has-text-align-center has-heading-4-font-size\" id=\"h-summary\" style=\"margin-top:calc(60px * var(--scale));margin-bottom:calc(30px * var(--scale))\"><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-teal-color\">Summary<\/mark><\/span><br><\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-heading-5-font-size\" id=\"h-increased-healthcare-costs-in-patients-with-iga-nephropathy-and-high-risk-proteinuria-and-worsening-kidney-function-1\"><span class=\"fw-600\">Increased healthcare costs in patients with IgA nephropathy and high-risk proteinuria and worsening kidney function<sup>1<\/sup><\/span><\/h3>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-heading-5-font-size\" id=\"h-background\"><br><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Background<\/mark><\/span><\/h4>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>IgA nephropathy is among the most common primary glomerular diseases in the US,<sup>2 <\/sup>and can progress to kidney failure.<sup>3<\/sup><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Current guidelines recommend management of blood pressure and proteinuria in IgA nephropathy to preserve kidney function, and angiotensin-converting enzyme inhibitors (ACEis) or angiotensin receptor blockers (ARBs) are recommended as initial therapy.<sup>4<\/sup> Guidelines also consider proteinuria \u22650.75\u20131 g\/day as high risk for progression and recommend reduction of proteinuria to &lt;1 g\/day as a therapeutic goal.<sup>4<\/sup><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>A previous literature review did not find a prevalence estimate of IgA nephropathy for the US,<sup>5<\/sup> and data on the associated <span style=\"text-decoration: underline;\"><a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/kidney-failure-iga-nephropathy-usrds-cohort-study\/\">economic burden<\/a><\/span> were also scarce.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-aim\"><br><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Aim<\/mark><\/span><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The aim of this study was to estimate the prevalence of IgA nephropathy in the US, describe the characteristics of this population and estimate healthcare resource utilization and costs for patients stratified by proteinuria level and chronic kidney disease (CKD) stage.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-approach\"><br><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Approach<\/mark><\/span><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>A retrospective cohort study was performed using the Optum database of electronic health record data including claims and prescription data from January 2007 to March 2021.<sup>1<\/sup> Patients in the prevalence cohort were identified based on disease and symptom entries related to IgA nephropathy, with index date defined as the first IgA nephropathy-related entry within the study period.<sup>1<\/sup> The healthcare resource utilization cohort was a subset of the prevalence cohort, of which patients also had to be \u226518 years old at index date, have \u22656 months of enrollment pre- and post-index, and have linked claims data.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-findings\"><br><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Findings<\/mark><\/span><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">Baseline demographics (Prevalence cohort: n=9,984)<sup>1<\/sup><\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li><span class=\"fw-600\">Age:<\/span> 44.9 years (91.9% aged \u226518 years)<\/li>\n\n\n\n<li><span class=\"fw-600\">Median follow-up:<\/span> 44 months<\/li>\n\n\n\n<li><span class=\"fw-600\">Male:<\/span> 57%<\/li>\n\n\n\n<li><span class=\"fw-600\">Median proteinuria:<\/span><strong> <\/strong>1.2 g\/day<\/li>\n\n\n\n<li><span class=\"fw-600\">Median estimated glomerular filtration rate (eGFR):<\/span> 56.3 mL\/min per 1.73m<sup>2<\/sup><\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">Prevalence of IgA nephropathy<\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The average estimated prevalence of IgA nephropathy in the US was 329.0 per 1,000,000.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>An increase in prevalence was observed over the study period (2016\u20132000).<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">Healthcare resource utilization and cost\/resource use cohort (n=813)<\/span><sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-left:calc(64px * var(--scale))\">\n<p><span class=\"fw-600\">High-risk proteinuria is associated with higher resource use and costs<sup>1<\/sup><\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Healthcare resource usage of patients with high-risk proteinuria (\u22651 g\/day) vs &lt;1 g\/day<sup>1<\/sup>:<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li><span class=\"fw-600\">Outpatient visits (mean per patient per month [PPPM]):<\/span> 3.49 vs 1.74; (<em>P<\/em>=0.01)<\/li>\n\n\n\n<li><span class=\"fw-600\">Pharmacy claims (mean PPPM):<\/span> 3.79 vs 2.41; (<em>P<\/em>=0.01)<\/li>\n\n\n\n<li><span class=\"fw-600\">Patients with an inpatient stay:<\/span> 32.3% vs 16.9%; (<em>P<\/em>=0.03)<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>There was a consistent trend towards higher costs associated with high-risk proteinuria across various elements of cost.<sup>1<\/sup> <\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Significantly higher outpatient costs and total costs were found for high-risk proteinuria patients vs &lt;1&nbsp;g\/day<sup>1<\/sup>:<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li><span class=\"fw-600\">Outpatient costs (mean, PPPM):<\/span> $1,848 vs $682; (<em>P<\/em>&lt;0.01)<\/li>\n\n\n\n<li><span class=\"fw-600\">Total costs (mean, PPPM):<\/span> $3,732 vs $1,457; (<em>P<\/em>=0.01)<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">Higher CKD stage is associated with higher resource use and costs<sup>1<\/sup><\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Similar differences were associated with higher CKD stages vs lower<sup>1<\/sup>:<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li><span class=\"fw-600\">Outpatient visits (mean, PPPM):<\/span> 1.94 Stage 1 vs 8.01 Stage 5 (<em>P<\/em>&lt;0.001)<\/li>\n\n\n\n<li><span class=\"fw-600\">Total costs (mean, PPPM):<\/span> $2,111 Stage 1 vs $10,703 Stage 5 (<em>P<\/em>&lt;0.001)<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-key-takeaway\"><br><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Key takeaway<\/mark><\/span><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Considering the rising prevalence of IgA nephropathy, treatments that can reduce proteinuria in IgA nephropathy and preserve kidney function may help reduce resource usage and healthcare costs.<sup>1<\/sup><br><br><br><br><br><\/p>\n\n\n\n<div class=\"newsletter\">\n\t<div class=\"newsletter-icon\">\n\t\t<span class=\"icon2-newsletter\"><\/span>\n\t<\/div>\n\t<div class=\"newsletter-text\">\n\t\t<p><strong>Sign up<\/strong> to receive scientific updates<br \/>\nfor healthcare professionals<br \/>\nfrom Travere Therapeutics.<\/p>\n\t<\/div>\n\t<div class=\"newsletter-form\">\n\t\t<script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\nvar 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ARB, angiotensin receptor blocker; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; PPPM, per patient per month; US, United States.<\/p>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ol class=\"wp-block-list\">\n<li class=\"has-small-font-size\">Lerma EV et al. <em>Kidney Med.<\/em> 2023;5(9):100693.&nbsp;<\/li>\n\n\n\n<li class=\"has-small-font-size\">McGrogan A et al. <em>Nephrol Dial Transplant.<\/em> 2011;26(2):414-430.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Nasri H, Mubarak M. <em>J Nephropathol.<\/em> 2015;4(1):1-5.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group. <em>Kidney Int.<\/em> 2021;100(4S):S1-S276.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Kwon CS et al. <em>Health Econ Outcomes Res.<\/em> 2021;8(2):36-45.<\/li>\n<\/ol>\n<\/div>\n\n\n<p class=\"has-text-align-right\" style=\"margin-top:calc(30px * var(--scale));margin-bottom:calc(300px * var(--scale))\">MA-DS-24-0033 | September 2024<\/p>\n<\/div>\n\n\t\t<\/div>\r\n\t<\/section>\r\n\t","protected":false},"featured_media":4893,"template":"","meta":{"inline_featured_image":false,"header_bg_color":"transparent","header_fixed":true,"post_description":"","post_download_link":"","journal_link":"https:\/\/www.kidneymedicinejournal.org\/article\/S2590-0595(23)00111-5\/fulltext","pdf_file_link":"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/Lerma-KM-2023-HEOR.pdf"},"product":[142],"therapeutic_area":[97],"disease_area":[174],"study_registry":[],"study_type":[191],"resource_type":[177,180],"class_list":["post-4904","publication","type-publication","status-publish","has-post-thumbnail","hentry","product-non-product-disease-state","therapeutic_area-neph","disease_area-igan","study_type-heor","resource_type-publication","resource_type-summary"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.9 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Prevalence and costs of IgA nephropathy in the US | Travere Medical Affairs<\/title>\n<meta name=\"description\" content=\"Learn more about the impact proteinuria and kidney function decline have on the economic burden associated with IgAN. 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