{"id":4892,"date":"2024-09-17T15:03:40","date_gmt":"2024-09-17T15:03:40","guid":{"rendered":"https:\/\/medicalaffairs.travere.com\/?post_type=publication&#038;p=4892"},"modified":"2025-09-30T23:53:19","modified_gmt":"2025-09-30T23:53:19","slug":"kidney-failure-iga-nephropathy-usrds-cohort-study","status":"publish","type":"publication","link":"https:\/\/clleancode.top\/travere-redesign\/publications\/kidney-failure-iga-nephropathy-usrds-cohort-study\/","title":{"rendered":"Kidney Failure Attributed to Immunoglobulin A Nephropathy: A USRDS Retrospective Cohort Study of Epidemiology, Treatment Modalities, and Economic Burden"},"content":{"rendered":"\n\n\n\n<section class=\"o-hero-section o-hero--banner o-hero--blue o-hero--cropped\">\n    <img decoding=\"async\" width=\"1920\" height=\"1080\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/09\/graph-money_header.png\" class=\"a-img a-img--right h-full\" alt=\"Hero Section Background Image\" loading=\"lazy\" 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href=\"https:\/\/clleancode.top\/travere-redesign\/\">Home<\/a><\/span><\/span><\/nav>            <\/div>\n            <h1 class=\"a-heading a-heading--h1 h-white\">Kidney Failure Attributed to Immunoglobulin A Nephropathy: A USRDS Retrospective Cohort Study of Epidemiology, Treatment Modalities, and Economic Burden<\/h1>                    <\/div>\n    <\/div>\n<\/section>\n\n\r\n\t<section style=\"margin-top:calc(-150px * var(--scale));\" class=\"section-container wp-block-grizzly-section-container\">\r\n\t\t\t\t<div class=\"container\">\r\n\t\t\t\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\">\n<div class=\"info-block info-block-publication search__container-publication search__container\">\n\t<div class=\"info-block-top\">\n\t\t<div>\n\t\t\t\t\t\t\t<div class=\"info-block-type\"><i class=\"icon2-journal\"><\/i> Journal article<\/div>\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"info-block-type\">\n\t\t\t\t\t<i class=\"icon2-calendar\"><\/i> Published on November 27, 2023\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t<p>Topics: <\/p>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">Nephrology<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">IgAN<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\t<div class=\"info-block-bottom\">\n\t\t\t\t\t<div class=\"info-block-box\">\n\t\t\t\tContributors:<br \/><span>Bensink M, Goldschmidt D, Zhou ZY et al.<\/span>\n\t\t\t<\/div>\n\t\t\n\t\t<div class=\"info-block-box\">\n\t\t\t\t\t\t\tName of Journal:<br \/><span>Kidney Medicine<\/span><br \/><br \/><br \/>\n\t\t\t\n\t\t\t\t\t\t\t<a href=\"#\" data-url=\"https:\/\/www.kidneymedicinejournal.org\/article\/S2590-0595(23)00177-2\/fulltext\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"btn btn-outline leaving-modal-toggle btn-leaving\" aria-label=\"View Publication\">View Publication<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"info-block-box info-block-doi\">\n\t\t\t\tDOI:<br \/><span>10.1016\/j.xkme.2023.100759<\/span>\n\t\t\t<\/div>\n\t\t\n\t\t<div class=\"info-block-share\">Share:\n\t\t\t<span>\n\t\t\t\t\t<a href=\"https:\/\/twitter.com\/intent\/tweet?url=https%3A%2F%2Fclleancode.top%2Ftravere-redesign%2Fpublications%2Fkidney-failure-iga-nephropathy-usrds-cohort-study%2F&#038;text=Kidney+Failure+Attributed+to+Immunoglobulin+A+Nephropathy%3A+A+USRDS+Retrospective+Cohort+Study+of+Epidemiology%2C+Treatment+Modalities%2C+and+Economic+Burden\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"icon2-x\" aria-label=\"Share on Twitter\"><\/a> \n\t<a href=\"https:\/\/www.linkedin.com\/shareArticle?url=https%3A%2F%2Fclleancode.top%2Ftravere-redesign%2Fpublications%2Fkidney-failure-iga-nephropathy-usrds-cohort-study%2F&#038;title=Kidney+Failure+Attributed+to+Immunoglobulin+A+Nephropathy%3A+A+USRDS+Retrospective+Cohort+Study+of+Epidemiology%2C+Treatment+Modalities%2C+and+Economic+Burden\" 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For more information, review the <a href=\"https:\/\/travere.com\/privacy\/\" target=\"_blank\">Travere privacy policies<\/a>.<\/span><\/label><\/span><\/span><\/span>\n  <\/div>\n  <div class=\"form-group text-right\">\n    <input class=\"wpcf7-form-control wpcf7-submit has-spinner btn\" id=\"request-submit\" type=\"submit\" value=\"Yes, continue\" \/>\n  <\/div>\n<\/div><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div> <\/div>\n\n\t\t<\/div>\r\n\t<\/section>\r\n\t\n\n\r\n\t<section style=\"padding-top:calc(30px * var(--scale));\" class=\"section-container wp-block-grizzly-section-container\">\r\n\t\t\t\t<div class=\"container\">\r\n\t\t\t\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading has-text-align-center has-heading-4-font-size\" id=\"h-summary\" style=\"padding-top:calc(60px * var(--scale));padding-bottom:calc(30px * var(--scale))\"><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-teal-color\">Summary<\/mark><\/span><br><\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-heading-5-font-size\" id=\"h-kidney-failure-due-to-iga-nephropathy-is-associated-with-high-economic-and-clinical-burdens-for-patients-and-the-healthcare-system-1\"><span class=\"fw-600\">Kidney failure due to IgA nephropathy is associated with high economic and clinical burdens for patients and the healthcare system<sup>1<\/sup><\/span><\/h3>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-heading-5-font-size\" id=\"h-background\"><br><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Background<\/mark><\/span><\/h4>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>IgA nephropathy is a rare disease arising from damage to the glomerular filtration barrier by IgA-mediated inflammation.<sup>2,3<\/sup> <span style=\"text-decoration: underline;\"><a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/clinicopathological-characteristics-of-adult-iga-nephropathy-in-the-united-states\/\">As the disease progresses patients develop<\/a><\/span><sup>3<\/sup>:<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li>Proteinuria<\/li>\n\n\n\n<li>Hematuria<\/li>\n\n\n\n<li>Decreased kidney function<\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Eventually, 15 to 40% of patients progress to developing kidney failure due to IgA nephropathy.<sup>4<\/sup> Disease progression is associated with greater patient and healthcare system burden.<sup>5<\/sup><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>There is <span style=\"text-decoration: underline;\"><a href=\"https:\/\/clleancode.top\/travere-redesign\/episode\/getting-ahead-of-igan\/\">no cure for IgA nephropathy<\/a><\/span>, but angiotensin-converting enzyme inhibitors (ACEis) and angiotensin II receptor blockers (ARBs) are recommended to control blood pressure and proteinuria.<sup>6<\/sup><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The lack of real-world evidence in the US on kidney failure due to IgA nephropathy is a barrier to addressing the unmet medical needs in this population.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-aim\"><br><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Aim<\/mark><\/span><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Using data from the US Renal Data System (USRDS) from 2008 to 2018, this study aimed to understand the epidemiology, characteristics, treatment patterns, and outcomes of patients with kidney failure due to IgA nephropathy.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-approach\"><br><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Approach<\/mark><\/span><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>This was a retrospective cohort study of patients with kidney failure due to IgA nephropathy identified in the USRDS, a national database covering all patients with kidney failure.<sup>1<\/sup> Data on patient demographics, treatment modalities, and clinical outcomes were summarized.<sup>1 <\/sup>Patients were followed from USRDS registration (index date) until loss to follow-up, data end, or death.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Healthcare resource utilization and costs were evaluated by analyzing a subgroup analysis of patients with \u22651 year of continuous Medicare coverage.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-findings\"><br><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Findings<\/mark><\/span><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">Prevalence and incidence<\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>During the study, the mean annual period prevalence and incidence of IgA nephropathy kidney failure in the US population was 39.3 and 2.9 per million persons, respectively.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Prevalence was higher among native Hawaiian\/Pacific Islanders (380.5 per million), followed by Asians (107.1 per million).<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">Baseline demographics<\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li><span class=\"fw-600\">Overall cohort:<\/span> 10,101 patients (including 1,696 in the Medicare Coverage subgroup)<sup>1<\/sup><\/li>\n\n\n\n<li><span class=\"fw-600\">Mean (SD) age at USRDS registration:<\/span><div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li><span class=\"fw-600\">Overall:<\/span> 47.7 (15.9) years<sup>1<\/sup><\/li>\n\n\n\n<li><span class=\"fw-600\">Medicare subgroup:<\/span> 59.7 (17.1) years<sup>1<\/sup><\/li>\n<\/ul>\n<\/div><\/li>\n\n\n\n<li><span class=\"fw-600\">Proportion male:<\/span><div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li><span class=\"fw-600\">Overall:<\/span> 65.8%<sup>1<\/sup><\/li>\n\n\n\n<li><span class=\"fw-600\">Medicare subgroup:<\/span> 66.6%<sup>1<\/sup><\/li>\n<\/ul>\n<\/div><\/li>\n\n\n\n<li><span class=\"fw-600\">Most common comorbid conditions in both groups:<\/span> Hypertension and diabetes<sup>1<\/sup><\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">Treatment modalities and clinical outcomes<\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>In the overall cohort:<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ul class=\"wp-block-list\">\n<li><span class=\"fw-600\">Mean follow-up time:<\/span> 64.0 months<sup>1<\/sup><\/li>\n\n\n\n<li><span class=\"fw-600\">Common treatment modalities at registration:<\/span> In-center hemodialysis (63.1%) and peritoneal dialysis (21.5%)<sup>1<\/sup><\/li>\n<\/ul>\n<\/div>\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">More than half of patients received a kidney transplant during follow-up<sup>1<\/sup><\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>15.1% of patients received a kidney transplant as their initial therapy, and by one year after the index date, this number had increased to 28.2% and up to 53.2% over the entire study period; the mean time to transplant was 3.8 years.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><span class=\"fw-600\">Healthcare resource utilization and economic burden was high<sup>1<\/sup><\/span><\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>In the Medicare Coverage subgroup, 74.4% required in-patient admission within the first year, with an average stay of 3.6 days per patient per month.<sup>1 <\/sup>Among patients in this subgroup with \u22651 year coverage, estimated mean annual healthcare costs were $63,402.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-key-takeaway\"><br><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\"><span class=\"fw-600\">Key takeaway<\/span><\/mark><\/h5>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Kidney failure due to IgA nephropathy imposes a <a href=\"https:\/\/clleancode.top\/travere-redesign\/?post_type=publication&amp;p=3764\"><span style=\"text-decoration: underline;\">great clinical<\/span> <\/a>and <span style=\"text-decoration: underline;\"><a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/iga-nephropathy-proteinuria-kidney-function-healthcare-costs\/\">economic burden<\/a><\/span> on patients and the healthcare system.<sup>1<\/sup> These findings highlight the need for novel therapies that delay or prevent the need for dialysis and transplantation to improve outcomes and reduce the clinical burden.<sup>1<\/sup><br><br><br><br><br><\/p>\n\n\n\n<div class=\"newsletter\">\n\t<div class=\"newsletter-icon\">\n\t\t<span class=\"icon2-newsletter\"><\/span>\n\t<\/div>\n\t<div class=\"newsletter-text\">\n\t\t<p><strong>Sign 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For more information, review the <a href=\"https:\/\/travere.com\/privacy\/\" target=\"_blank\" rel=\"noopener\">Travere  privacy policies<\/a>.<\/p>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div id=\"invalid-newsletter\" class=\"invalid\">\n\t\t\t<div id=\"invalid-box-newsletter\">\n\t\t\t\t<span class=\"icon2-info-fill\"><\/span>\n\t\t\t<\/div>\n\t\t\t<div>\n\t\t\t\t<p><strong>Invalid email address.<\/strong><br \/>\n\t\t\t\tMake sure email is in correct format: <a href=\"\">name@example.com<\/a><\/p>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\t<div class=\"publication-related\">\n\t\t<p class=\"has-heading-4-font-size\">Related Content<\/p>\n\t\t<div class=\"publication-related-swiper-container\" style=\"display: none;\">\n\t\t\t<div class=\"swiper publicationSwiper\">\n\t\t\t\t<div class=\"swiper-wrapper\">\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"swiper-slide\">\n\t\t\t\t\t\t\t\t<article class=\"m-card  \" aria-label=\"Publication card: Clinicopathological Characteristics of Adult IgA Nephropathy in the United States\">\n\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/clinicopathological-characteristics-of-adult-iga-nephropathy-in-the-united-states\/\"  aria-label=\"View publication: Clinicopathological Characteristics of Adult IgA Nephropathy in the United States\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1920\" height=\"767\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/pathology-of-igan_header.png\" class=\"a-img\" alt=\"Clinicopathological Characteristics of Adult IgA Nephropathy in the United States\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/pathology-of-igan_header.png 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/pathology-of-igan_header-300x120.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/pathology-of-igan_header-1024x409.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/pathology-of-igan_header-768x307.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/pathology-of-igan_header-1536x614.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/pathology-of-igan_header-290x116.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t<\/a>\n\t\t\t<div class=\"m-card__info\">\n\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t<span class=\"a-tag h-blue\">\n\t\t\t\t\t\t<i class=\"icon4 icon4-publication\"><\/i> Publication\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"a-tag h-blue\">Nephrology<\/span><span class=\"a-tag h-blue\">IgAN<\/span>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t<div class=\"m-card__text\">\n\t\t\t\t<p class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\tClinicopathological Characteristics of Adult IgA Nephropathy in the United States\t\t\t\t<\/p>\n\t\t\t\t<p class=\"a-text a-text--m h-ultra-dark-blue\">\n\t\t\t\t\t<em>Kidney International Reports<\/em> \n\t\t\t\t\t &#8211; \t\t\t\t\t2023\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/clinicopathological-characteristics-of-adult-iga-nephropathy-in-the-united-states\/\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: Clinicopathological Characteristics of Adult IgA Nephropathy in the United States\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"swiper-progressbar\"><\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"publication-related-grid search-items__grid search__container\" id=\"search__container\" style=\"display: flex;\">\n\t\t\t\t<article class=\"m-card  \" aria-label=\"Publication card: Clinicopathological Characteristics of Adult IgA Nephropathy in the United States\">\n\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/clinicopathological-characteristics-of-adult-iga-nephropathy-in-the-united-states\/\"  aria-label=\"View publication: Clinicopathological Characteristics of Adult IgA Nephropathy in the United States\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1920\" height=\"767\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/pathology-of-igan_header.png\" class=\"a-img\" alt=\"Clinicopathological Characteristics of Adult IgA Nephropathy in the United States\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/pathology-of-igan_header.png 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/pathology-of-igan_header-300x120.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/pathology-of-igan_header-1024x409.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/pathology-of-igan_header-768x307.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/pathology-of-igan_header-1536x614.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/pathology-of-igan_header-290x116.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t<\/a>\n\t\t\t<div class=\"m-card__info\">\n\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t<span class=\"a-tag h-blue\">\n\t\t\t\t\t\t<i class=\"icon4 icon4-publication\"><\/i> Publication\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"a-tag h-blue\">Nephrology<\/span><span class=\"a-tag h-blue\">IgAN<\/span>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t<div class=\"m-card__text\">\n\t\t\t\t<p class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\tClinicopathological Characteristics of Adult IgA Nephropathy in the United States\t\t\t\t<\/p>\n\t\t\t\t<p class=\"a-text a-text--m h-ultra-dark-blue\">\n\t\t\t\t\t<em>Kidney International Reports<\/em> \n\t\t\t\t\t &#8211; \t\t\t\t\t2023\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/clinicopathological-characteristics-of-adult-iga-nephropathy-in-the-united-states\/\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: Clinicopathological Characteristics of Adult IgA Nephropathy in the United States\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t\t<\/div>\n\t\t<div class=\"publication-related-btn\">\n\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/\" class=\"a-btn a-btn--primary\" aria-label=\"See more\">See more<\/a>\n\t\t<\/div>\n\t<\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-footnotes\"><span class=\"fw-600\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ocean-blue-color\">Footnotes<\/mark><\/span><\/h5>\n\n\n\n<p class=\"has-small-font-size\"><br>ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin II receptor blocker; IgA, immunoglobulin A; US, United States; USRDS, US Renal Data System.<\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ol class=\"wp-block-list\">\n<li class=\"has-small-font-size\">Bensink ME et al. <em>Kidney Med<\/em>. 2023;6(2):100759.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Wyatt RJ, Julian BA. <em>N Engl J Med<\/em>. 2013;368(25):2402-2414.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Fabiano RCG et al. <em>Inflam Res<\/em>. 2016;65(10):757-770.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Donadio JV, Grande JP. <em>N Engl J Med<\/em>. 2002;347(10):738-748.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Kwon CS et al. <em>J Health Econ Outcomes Res<\/em>. 2021;8(2):36-45.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Floege J et al. <em>Sem Immunopathol<\/em>. 2021;43(5):717-728.<\/li>\n<\/ol>\n<\/div>\n\n\n<p class=\"has-text-align-right\" style=\"margin-bottom:calc(300px * var(--scale));padding-top:calc(30px * var(--scale));padding-bottom:calc(30px * var(--scale))\">MA-DS-24-0031 | September 2024<\/p>\n<\/div>\n\n\t\t<\/div>\r\n\t<\/section>\r\n\t","protected":false},"featured_media":4893,"template":"","meta":{"inline_featured_image":false,"header_bg_color":"transparent","header_fixed":true,"post_description":"","post_download_link":"","journal_link":"https:\/\/www.kidneymedicinejournal.org\/article\/S2590-0595(23)00177-2\/fulltext","pdf_file_link":""},"product":[142],"therapeutic_area":[97],"disease_area":[174],"study_registry":[190],"study_type":[191,182],"resource_type":[177,180],"class_list":["post-4892","publication","type-publication","status-publish","has-post-thumbnail","hentry","product-non-product-disease-state","therapeutic_area-neph","disease_area-igan","study_registry-usrds","study_type-heor","study_type-observational","resource_type-publication","resource_type-summary"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.9 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Kidney Failure Due to IgAN: Burden of Disease From the USRDS Cohort | Travere Medical Affairs<\/title>\n<meta name=\"description\" content=\"Learn more about the high burden of disease in patients with kidney failure due to IgAN. 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