{"id":4601,"date":"2023-06-01T22:32:00","date_gmt":"2023-06-01T22:32:00","guid":{"rendered":"https:\/\/medicalaffairs.travere.com\/?post_type=publication&#038;p=4601"},"modified":"2025-09-30T23:57:25","modified_gmt":"2025-09-30T23:57:25","slug":"long-term-outcomes-in-iga-nephropathy","status":"publish","type":"publication","link":"https:\/\/clleancode.top\/travere-redesign\/publications\/long-term-outcomes-in-iga-nephropathy\/","title":{"rendered":"Long-Term Outcomes in IgA Nephropathy"},"content":{"rendered":"\n\n\n\n<section class=\"o-hero-section o-hero--banner o-hero--blue o-hero--cropped\">\n    <img decoding=\"async\" width=\"1920\" height=\"767\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1.png\" class=\"a-img a-img--right h-full\" alt=\"Hero Section Background Image\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1.png 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1-300x120.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1-1024x409.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1-768x307.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1-1536x614.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1-290x116.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>    <div class=\"container\">\n        <div class=\"m-hero-inner m-hero-inner--post\">\n            <div class=\"m-breadcrumb\">\n                <nav class=\"breadcrumbs\" aria-label=\"breadcrumb\"><span><span><a href=\"https:\/\/clleancode.top\/travere-redesign\/\">Home<\/a><\/span><\/span><\/nav>            <\/div>\n            <h1 class=\"a-heading a-heading--h1 h-white\">Long-Term Outcomes in IgA Nephropathy<\/h1>                    <\/div>\n    <\/div>\n<\/section>\n\n\r\n\t<section style=\"margin-top:calc(-150px * var(--scale));\" class=\"section-container wp-block-grizzly-section-container\">\r\n\t\t\t\t<div class=\"container\">\r\n\t\t\t\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\">\n<div class=\"info-block info-block-publication search__container-publication search__container\">\n\t<div class=\"info-block-top\">\n\t\t<div>\n\t\t\t\t\t\t\t<div class=\"info-block-type\"><i class=\"icon2-journal\"><\/i> Journal article<\/div>\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"info-block-type\">\n\t\t\t\t\t<i class=\"icon2-calendar\"><\/i> Published on June 1, 2023\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t<p>Topics: <\/p>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">Nephrology<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">IgAN<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\t<div class=\"info-block-bottom\">\n\t\t\t\t\t<div class=\"info-block-box\">\n\t\t\t\tContributors:<br \/><span>Pitcher D, Braddon F, Hendry B et\u00a0al.<\/span>\n\t\t\t<\/div>\n\t\t\n\t\t<div class=\"info-block-box\">\n\t\t\t\t\t\t\tName of Journal:<br \/><span>Clinical Journal of the American Society of Nephrology<\/span><br \/><br \/><br \/>\n\t\t\t\n\t\t\t\t\t\t\t<a href=\"#\" data-url=\"https:\/\/journals.lww.com\/cjasn\/fulltext\/2023\/06000\/long_term_outcomes_in_iga_nephropathy.9.aspx\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"btn btn-outline leaving-modal-toggle btn-leaving\" aria-label=\"View Publication\">View Publication<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"info-block-box info-block-doi\">\n\t\t\t\tDOI:<br \/><span>10.2215\/CJN.0000000000000135<\/span>\n\t\t\t<\/div>\n\t\t\n\t\t<div class=\"info-block-share\">Share:\n\t\t\t<span>\n\t\t\t\t\t<a href=\"https:\/\/twitter.com\/intent\/tweet?url=https%3A%2F%2Fclleancode.top%2Ftravere-redesign%2Fpublications%2Flong-term-outcomes-in-iga-nephropathy%2F&#038;text=Long-Term+Outcomes+in+IgA+Nephropathy\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"icon2-x\" aria-label=\"Share on Twitter\"><\/a> \n\t<a href=\"https:\/\/www.linkedin.com\/shareArticle?url=https%3A%2F%2Fclleancode.top%2Ftravere-redesign%2Fpublications%2Flong-term-outcomes-in-iga-nephropathy%2F&#038;title=Long-Term+Outcomes+in+IgA+Nephropathy\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"icon2-linkedin-2\" aria-label=\"Share on LinkedIn\"><\/a> \n\t<a href=\"https:\/\/www.facebook.com\/sharer\/sharer.php?u=https%3A%2F%2Fclleancode.top%2Ftravere-redesign%2Fpublications%2Flong-term-outcomes-in-iga-nephropathy%2F\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"icon-facebook\" aria-label=\"Share on Facebook\"><\/a> \n\t<a 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For more information, review the <a href=\"https:\/\/travere.com\/privacy\/\" target=\"_blank\">Travere privacy policies<\/a>.<\/span><\/label><\/span><\/span><\/span>\n  <\/div>\n  <div class=\"form-group text-right\">\n    <input class=\"wpcf7-form-control wpcf7-submit has-spinner btn\" id=\"request-submit\" type=\"submit\" value=\"Yes, continue\" \/>\n  <\/div>\n<\/div><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div> <\/div>\n\n\t\t<\/div>\r\n\t<\/section>\r\n\t\n\n\r\n\t<section class=\"section-container wp-block-grizzly-section-container\">\r\n\t\t\t\t<div class=\"container\">\r\n\t\t\t\n\n<div class=\"wp-block-group is-layout-constrained wp-container-core-group-is-layout-09ab29e6 wp-block-group-is-layout-constrained\" style=\"margin-top:calc(50px * var(--scale))\">\n<div class=\"event-video\" id=\"video\">\n\t\t\t<p class=\"has-heading-3-font-size\">About this study<\/p>\n\t\t\n\t<a href=\"#\" class=\"event-video--img\" style=\"background-image: url('https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/Long-term-outcomes-video.png');\">\n\t\t<span class=\"icon2-play\" aria-hidden=\"true\"><\/span>\n\t<\/a>\n\t\n\t<div class=\"event-video--vimeo\"><\/div>\n\t\n\t<\/div>\n\n<script src=\"https:\/\/player.vimeo.com\/api\/player.js\"><\/script>\n<script>\n\tdocument.addEventListener(\"DOMContentLoaded\", function() {\n\t\tconst imgLink = document.querySelector(\".event-video--img\");\n\t\tconst vimeoDiv = document.querySelector(\".event-video--vimeo\");\n\t\tlet iframeExists = false;\n\t\tlet player;\n\n\t\timgLink.addEventListener(\"click\", function(event) {\n\t\t\tevent.preventDefault();\n\n\t\t\tif (!iframeExists) {\n\t\t\t\tconst iframe = document.createElement(\"iframe\");\n\t\t\t\tiframe.src = \"https:\/\/player.vimeo.com\/video\/1096925557\";\n\t\t\t\tiframe.frameBorder = \"0\";\n\t\t\t\tiframe.allow = \"autoplay; fullscreen\";\n\t\t\t\tiframe.allowFullscreen = true;\n\t\t\t\tvimeoDiv.appendChild(iframe);\n\t\t\t\t\n\t\t\t\tplayer = new Vimeo.Player(iframe);\n\t\t\t\tplayer.play();\n\t\t\t\tiframeExists = true;\n\t\t\t}\n\n\t\t\tvimeoDiv.style.display = \"block\";\n\t\t\timgLink.style.display = \"none\";\n\t\t});\n\n\t\tvimeoDiv.addEventListener(\"click\", function() {\n\t\t\tconst iframe = vimeoDiv.querySelector(\"iframe\");\n\t\t\tiframe.contentWindow.postMessage('{\"method\":\"play\"}', 'https:\/\/player.vimeo.com\/video\/1096925557');\n\t\t});\n\t});\n<\/script>\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>See video transcript<\/summary>\n<p>Primary IgA nephropathy is the most common type of glomerulonephritis and a major cause of chronic kidney disease and kidney failure worldwide. Current understanding of the risk of progression has been based on data from short-term trials, highlighting the need for surrogate endpoints that can predict long-term outcomes. Regulatory authorities have accepted reduction in proteinuria as an appropriate surrogate endpoint for IgA nephropathy trials, but questions still remain. <br><br>To better understand long-term IgA nephropathy outcomes in patients traditionally considered low risk for kidney failure, data from the UK National Registry of Rare Kidney Diseases, RaDaR, were retrospectively analyzed. Patient eligibility included biopsy-proven primary IgA nephropathy and proteinuria above 0.5 g\/day or estimated glomerular filtration rate \u2013 eGFR \u2013 below 60 mL\/min\/1.73 m<sup>2<\/sup>. In total, 2,439 patients were analyzed. <br><br>Outcomes in this large cohort of patients were generally poor. The median follow-up was 5.9 years, during which 50% of patients reached kidney failure or died. Findings demonstrated a significant association between persistent proteinuria and rapid loss of eGFR and worse kidney survival. Higher time-averaged levels of proteinuria were significantly associated with more rapid progression to kidney failure or death. Across all proteinuria levels, patients with IgA nephropathy, including those traditionally considered \u201clow risk\u201d, were at risk of developing kidney failure within 10 years. Analyses also showed that patients with a more rapid eGFR loss had a lower 5-year kidney survival rate.<\/p>\n\n\n\n<p><br>The poor outcomes observed in the RaDaR registry highlighted the need to re-evaluate the current approach to patient care in IgA nephropathy, particularly the need to target a lower threshold of proteinuria, consider combination therapies, and implement a lower threshold for biopsy.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n<\/details>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center has-heading-4-font-size has-teal-color has-text-color has-link-color wp-elements-00c85ba9b6914cc0febb43511828b16c\" id=\"h-summary\" style=\"margin-top:calc(60px * var(--scale));margin-bottom:calc(30px * var(--scale))\"><strong>Summary<\/strong><\/h2>\n\n\n\t<div class=\"feature-block feature-block--left\">\n\t\t\t\t\t\t\t<div class=\"feature-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"has-heading-5-font-size\">Background<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p><ul>\n<li>Primary IgA nephropathy is the most common form of glomerulonephritis and a major cause of chronic kidney disease (CKD) and kidney failure worldwide<sup>1,2<sup><\/li>\n<li>Current understanding of the risk of progression has been based on data from short-term trials, highlighting the need for surrogate clinical trial endpoints that can predict long-term outcomes<\/li>\n<li><p>Regulatory authorities have accepted reduction in proteinuria as an appropriate surrogate endpoint for IgA nephropathy trials but questions still remain<sup>3<sup> <\/p> <p><ul style=&#8221;margin:0; margin-left: 25px; padding:0; align=&#8221;left&#8221;><p><li>To what extent can short-term changes in proteinuria and estimated glomerular filtration rate (eGFR) data predict IgA nephropathy outcomes?<\/p><li>What degree of proteinuria reduction would result in a slower eGFR decline? <\/p><\/ul><\/p><\/li>\n<\/ul>\n<\/p>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"m-card\">\n\t\t\t\t\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1920\" height=\"767\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1.png\" class=\"a-img\" alt=\"Explore the RaDaR Plain Language Summary\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1.png 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1-300x120.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1-1024x409.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1-768x307.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1-1536x614.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-header-1-290x116.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"m-card__info\">\n\t\t\t\t\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag a-tag--blue\">Downloadable Resource<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"a-tag\">Nephrology<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t\t\t\t\t<div class=\"m-card__text\">\n\t\t\t\t\t\t\t\t<h4 class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\t\t\t\t\tExplore the RaDaR Plain Language Summary\t\t\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2025\/02\/RaDaR-Long-term-outcomes-IgAN-PLS.pdf\" target=\"_blank\" rel=\"noopener\" class=\"a-btn a-btn--secondary--blue\">\n\t\t\t\t\t\t\t\t\t\t<span>View RaDaR PLS<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\n<div class=\"publication-aim\">\n\t<div class=\"publication-aim-left\">\n\t\t<p class=\"has-heading-5-font-size\">Aim<\/p>\n\t\t<p>To better understand long-term IgA nephropathy outcomes in patients traditionally considered &#8220;low risk&#8221; (&lt;1 g\/day) for kidney failure, data from the UK National Registry of Rare Kidney Diseases (RaDaR) were retrospectively analyzed<\/p>\n\t<\/div>\n\t<div class=\"publication-aim-right\">\n\t\t<p><\/p>\n\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-logo-1.png\" data-fancybox=\"images\" aria-label=\"View image\">\n\t\t\t<img decoding=\"async\" width=\"1037\" height=\"563\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-logo-1.png\" class=\"attachment-full size-full\" alt=\"Aim\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-logo-1.png 1037w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-logo-1-300x163.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-logo-1-1024x556.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-logo-1-768x417.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/RaDaR-logo-1-290x157.webp 290w\" sizes=\"auto, (max-width: 1037px) 100vw, 1037px\" \/>\t\t<\/a>\n\t\t\t<\/div>\n<\/div>\n\n\n<div class=\"key-findings\">\n\t<p class=\"has-heading-5-font-size\">Key findings<\/p>\n\t\n\t\t\t\t<div class=\"key-findings-list\" style=\"--key-finding-items: 4;\">\n\t\t\t\t\t\t\t\t\t<div class=\"key-finding-item\">\n\t\t\t\t\t\t<img decoding=\"async\" width=\"297\" height=\"276\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/radar-key-findings-1.png\" class=\"attachment-full size-full\" alt=\"Key Finding Image\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/radar-key-findings-1.png 297w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/radar-key-findings-1-290x269.webp 290w\" sizes=\"auto, (max-width: 297px) 100vw, 297px\" \/>\t\t\t\t\t\t<p>Outcomes in this large cohort of patients with IgA nephropathy were generally poor, including in patients traditionally considered &#8220;low risk&#8221; (&lt;1 g\/day)<\/p>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"key-finding-item\">\n\t\t\t\t\t\t<img decoding=\"async\" width=\"298\" height=\"276\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/radar-key-findings-2.png\" class=\"attachment-full size-full\" alt=\"Key Finding Image\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/radar-key-findings-2.png 298w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/radar-key-findings-2-290x269.webp 290w\" sizes=\"auto, (max-width: 298px) 100vw, 298px\" \/>\t\t\t\t\t\t<p>Few patients were expected to avoid kidney failure in their lifetime<\/p>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"key-finding-item\">\n\t\t\t\t\t\t<img decoding=\"async\" width=\"299\" height=\"276\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/radar-key-findings-3.png\" class=\"attachment-full size-full\" alt=\"Key Finding Image\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/radar-key-findings-3.png 299w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/radar-key-findings-3-290x268.webp 290w\" sizes=\"auto, (max-width: 299px) 100vw, 299px\" \/>\t\t\t\t\t\t<p>The data suggest that proteinuria had a strong predictive value for the progression of IgA nephropathy, including in low risk patients<\/p>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"key-finding-item\">\n\t\t\t\t\t\t<img decoding=\"async\" width=\"298\" height=\"276\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/radar-key-findings-4.png\" class=\"attachment-full size-full\" alt=\"Key Finding Image\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/radar-key-findings-4.png 298w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/radar-key-findings-4-290x269.webp 290w\" sizes=\"auto, (max-width: 298px) 100vw, 298px\" \/>\t\t\t\t\t\t<p>Persistent proteinuria was significantly associated with more rapid loss of eGFR and worse kidney survival<\/p>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t<\/div>\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"conclusions\">\n\t\t\t<p class=\"has-heading-5-font-size\">Conclusions<\/p>\n\t\n\t<div class=\"conclusions-inner\">\n\t\t<div class=\"conclusions-left\">\n\t\t\t\t\t\t\t<p>RaDaR demonstrated a growing need to:<\/p>\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"conclusions-list\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"conclusions-list-item\">Target a lower threshold of proteinuria than already accepted and a lower rate of eGFR loss<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"conclusions-list-item\">Consider combination treatments to maximize effectiveness<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"conclusions-list-item\">Implement a lower threshold for biopsy to allow for earlier diagnosis and treatment initiation<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"conclusions-list-item\">Overall, findings suggest that the current approach to patient care needs to be re-evaluated to improve clinical outcomes<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t<div class=\"conclusions-right\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"901\" height=\"777\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/Iga-nephropathy-outcomes-conclusions.png\" class=\"attachment-full size-full\" alt=\"Triangle and lightbulb\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/Iga-nephropathy-outcomes-conclusions.png 901w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/Iga-nephropathy-outcomes-conclusions-300x259.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/Iga-nephropathy-outcomes-conclusions-768x662.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2023\/10\/Iga-nephropathy-outcomes-conclusions-290x250.webp 290w\" sizes=\"auto, (max-width: 901px) 100vw, 901px\" 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https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-300x169.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-1024x576.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-768x432.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-1536x864.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-290x163.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t<\/a>\n\t\t\t<div class=\"m-card__info\">\n\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t<span class=\"a-tag h-blue\">\n\t\t\t\t\t\t<i class=\"icon4 icon4-publication\"><\/i> Publication\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"a-tag h-blue\">Nephrology<\/span><span class=\"a-tag 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United States\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t<article class=\"m-card  \" aria-label=\"Publication card: Kidney Failure Events, Cardiovascular Disease Events, and All-Cause Mortality in Immunoglobulin A Nephropathy Patients in a Real-World Database\">\n\t\t<div class=\"m-card__top\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/iga-nephropathy-mortality-kidney-failure-cardiovascular-disease-real-world\/\"  aria-label=\"View publication: Kidney Failure Events, Cardiovascular Disease Events, and All-Cause Mortality in Immunoglobulin A Nephropathy Patients in a Real-World Database\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1920\" height=\"1080\" src=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header.png\" class=\"a-img\" alt=\"Kidney Failure Events, Cardiovascular Disease Events, and All-Cause Mortality in Immunoglobulin A Nephropathy Patients in a Real-World Database\" loading=\"lazy\" srcset=\"https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header.png 1920w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-300x169.webp 300w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-1024x576.webp 1024w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-768x432.webp 768w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-1536x864.webp 1536w, https:\/\/clleancode.top\/travere-redesign\/wp-content\/uploads\/2024\/03\/people-world-map_header-290x163.webp 290w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t<\/a>\n\t\t\t<div class=\"m-card__info\">\n\t\t\t\t<div class=\"m-tags\">\n\t\t\t\t\t<span class=\"a-tag h-blue\">\n\t\t\t\t\t\t<i class=\"icon4 icon4-publication\"><\/i> Publication\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"a-tag h-blue\">Nephrology<\/span><span class=\"a-tag h-blue\">IgAN<\/span>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"m-card__bottom m-card--padding\">\n\t\t\t<div class=\"m-card__text\">\n\t\t\t\t<p class=\"a-heading a-heading--h4 h-ultra-dark-blue h-text-ellipsis h-w-medium\">\n\t\t\t\t\tKidney Failure Events, Cardiovascular Disease Events, and All-Cause Mortality in Immunoglobulin A Nephropathy Patients in a Real-World Database\t\t\t\t<\/p>\n\t\t\t\t<p class=\"a-text a-text--m h-ultra-dark-blue\">\n\t\t\t\t\t<em>Kidney360<\/em> \n\t\t\t\t\t &#8211; \t\t\t\t\t2024\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/iga-nephropathy-mortality-kidney-failure-cardiovascular-disease-real-world\/\" class=\"a-btn a-btn--secondary--blue\"  aria-label=\"Read more: Kidney Failure Events, Cardiovascular Disease Events, and All-Cause Mortality in Immunoglobulin A Nephropathy Patients in a Real-World Database\">\n\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\t\t<\/div>\n\t\t<div class=\"publication-related-btn\">\n\t\t\t<a href=\"https:\/\/clleancode.top\/travere-redesign\/publications\/\" class=\"a-btn a-btn--primary\" aria-label=\"See more\">See more<\/a>\n\t\t<\/div>\n\t<\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading has-heading-5-font-size has-ocean-blue-color has-text-color has-link-color wp-elements-2e89a46291e632fc5b6e98708e64fb62\" id=\"h-footnotes\" style=\"margin-bottom:calc(30px * var(--scale))\"><strong>Footnotes<\/strong><\/h3>\n\n\n\n<p class=\"has-small-font-size\" style=\"margin-bottom:calc(30px * var(--scale))\">CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; IgA, immunoglobulin A; UK, United Kingdom.<\/p>\n\n\n<div class=\"wp-block-list-wrapper\">\n<ol class=\"wp-block-list\">\n<li class=\"has-small-font-size\">McGrogan A et al. <em>Nephrol Dial Transplant.<\/em> 2011;26(2):414-430.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Canney M et al. <em>J Am Soc Nephrol<\/em>. 2021;32(2):436-447.<\/li>\n\n\n\n<li class=\"has-small-font-size\">Thompson A et al. <em>Clin J Am Soc Nephrol<\/em>. 2019;14(3):469-481.<\/li>\n<\/ol>\n<\/div>\n\n\n<p class=\"has-text-align-right\" style=\"margin-top:calc(30px * var(--scale));margin-bottom:calc(300px * var(--scale))\">MA-DS-24-0006 | June 2025<\/p>\n<\/div>\n\n\t\t<\/div>\r\n\t<\/section>\r\n\t","protected":false},"featured_media":4578,"template":"","meta":{"inline_featured_image":false,"header_bg_color":"transparent","header_fixed":true,"post_description":"","post_download_link":"","journal_link":"https:\/\/journals.lww.com\/cjasn\/fulltext\/2023\/06000\/long_term_outcomes_in_iga_nephropathy.9.aspx","pdf_file_link":""},"product":[142],"therapeutic_area":[97],"disease_area":[174],"study_registry":[184],"study_type":[182,183],"resource_type":[185,177,178],"class_list":["post-4601","publication","type-publication","status-publish","has-post-thumbnail","hentry","product-non-product-disease-state","therapeutic_area-neph","disease_area-igan","study_registry-radar","study_type-observational","study_type-rwe","resource_type-pls","resource_type-publication","resource_type-video"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.9 (Yoast SEO v27.4) - 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